© 2017 by OPC-DOC

ADD

Effect of OPCs - ADD

 

The attention deficit disorder is a disorder that is often diagnosed nowadays when it's about inexplicable behavior of children (meanwhile even with grown-ups). Thereby, a lot of medicine is being prescribed in order to  reduce the symptoms when ADD is being "discovered".

Since OPCs (oligomer proanthocyanidins) overcome the blood-cerebral barrier and contain special strong antioxidant and antiphlogistic (anti-inflammatory) features, they can also be used for ADD. If an overload with free radicals is involved in the ADD symptoms, over time the supplementation with OPC will have a positive effect. The effect of free radicals (emerge through aggressive oxidation processes) are neutralized through OPCs and the ADD symptoms can possibly be reduced already through that.

If inflammatory process underlie the ADD, then the OPCs will also work perfectly. The reason for that is that OPCs block the enzyme hyaluronidase. In its active form, the enzyme releases histamine an inflammatory stimulating effect. With the OPC induced blockades of hyaluronidase the histamine release is being modulated and inflammatory processes are mellowed. Since there are relatively less experiences with the usage of OPCs and ADD (or ADHD = attention deficit hyperactivity disorder) there is only few feedback from parents. This of course could also be, due to the low amount of OPC products that are really able to unfold the effect that Professor Masquelier discovered.

In order to work, it's curial that the OPCs are manufactured according to the patented original procedure of Professor Masquelier (pine bark extract and/or grape seed extract) and that they contain a relatively low amount of vitamin C (the effect of vitamin C is being increased 10fold = 1000% with OPCs).

 

Ultimately it can only be positive for the ADD patient to try taking OPCs for a time frame of at least 8 - 12 weeks, since OPCs have especially exceptional effects if you take them for a long time.

Thereby, one should take at least 200mg of OPCs daily (at best in combination with vitamin C, at least 80 - 120mg/day)

Consequential Damages of Alcohol

Effect of OPC - Consequential Damages of Alcohol

 

Can OPC reduce the consequential damages of alcohol? This question is very  important, because the excessive consume of alcohol is an extreme risk factor for health. While low alcohol consume can still be euphoriant and stimulating, a higher consumption of alcohol can lead to consequential damages that can lead to nausea / vomiting, vertigo, diarrhea, racing heart, sweating attacks, language difficulties / babbling up to depression and the well-known hangover.

When it comes to long-term alcohol abuse, an addiction can be developed just like with any other addictive drug and lead to diseases like hepatic cirrhosis, cancer, dementia, high blood pressure and other cardiovascular diseases. The vessels of people that are addicted to alcohol are often heavily damaged. Thereby free radicals play a huge part that attack the different body systems.

 

It's proven that OPCs are the strongest "radical captors".  They tackle the root of the "oxidation problem" and give electrons to the aggressive oxygen molecules. This way, OPCs prevent aggressive oxidation processes that are representative for consequential damages of alcohol.

With a daily amount of 100 - 200 mg of OPCs over a long period of time (this of course is dependent on the extent of consequential damages of alcohol and can extend from a few months up to several years) consequential damages of alcohol can be reduced bit by bit. A requirement for this of course is that the harmful alcohol consume is being stopped in order to live healthier.

 

Consequential damages of alcohol are characterized by:

 

·        ·         Inflammatory Processes
 

·        ·         Damage of the vessel system
 

·        ·        Cardiovascular disease
 

·        ·        Tissue Damages due to free radicals

 

All of these consequential damages of alcohol can be treated brilliantly with OPCs in a natural way, when the OPC product has the necessary quality and is based on the research of the OPC inventor Professor Jaques Masquelier.

 

Sources

 

Anne Simons - Das OPC-Arbeitsbuch Netdoktor.at - Mag. Axel Beer WHO: Global Status Report on Alcohol and Health 2011

http://www.who.int/substance_abuse/publications/global_alcohol_report/en/ Deutsche Gesellschaft für Suchtforschung: D3 Leitlinien

http://www.dg-sucht.de/s3-leitlinien/ AOK: Keine Entwarnung bei Suchterkrankungen – neue Suchtmittel auf dem Vormarsch

http://www.aok-bv.de/presse/pressemitteilungen/2013/index_10523.html

IHS: http://www.ihs.ac.at/publications/lib/presseinfo_alkoholkrankheit_250713.pdf

Allergies

Effect of OPCs - Allergies

How can OPC help fighting allergies? Allergies are characterized by inflammatory reactions where the immune system overreacts. This immune answer is being initiated by cells whose job it is to discover, evaluate and if necessary eliminate "foreign matter" in the organism. An allergy occurs when this mechanism is disturbed. Often, free radicals play a part here, that can be perfectly reduced by using OPCs.

The crucial substance in the body, however, is histamine, that is produced in so called mast cells. One of the most important mediators if you want to get a grip on the allergy with the help of OPCs is histamine. When the histamine production, resp. the histamine release can be modulated, inflammation processes could be reduced by that.

This was already presented by Dr. D. White of the medical faculty of the University of Nottingham on the international OPC symposium (international conference of OPC research in Bordeaux, France) in 1990. According to him, the development of histamine and the consequent unwanted inflammation processes can be optimally reduced with OPCs.

Additionally the histamine producing mast cells are prevented from degranulation and thereby the so-called granules (all saved antigens and messengers n the mast cell) are opened up. With this positive influence of OPC on the degranulation of the mast cells, OPCs can reduce allergies as such.

Depending on the type of allergy one should supplement 2mg / kg bodyweight / day when starting with OPCs (example: a person that weights 80 kg takes 160 mg of OPCs daily). Thereby one should pay attention to the quality. A successful treatment can definitely depend on the period that it's being taken - the more severe the allergy is, the longer it can take until the symptoms are reduced. Thereby, OPCs can also perfectly be used as a supporting measure while taking medicine.

Sources

Dr. Walter Brohmüller-Scholte – Buch: OPC – Das Super-Antioxidans

Inflammation and Nutrition, Anon. Medical Nutrition (Medizinische Ernährung), 42-5 (Herbst 1989)

 

Dr. David White – Internationale Konferenz OPC-Forschung, Bordeaux / Frankreich, 1990

Shear stress and aortic histamine synthesis; De- Forrest, Jack M. und Hollis, Theodore M, Amer. J. Physiol. 234(6) H701-5 (1978)

Mastzell-Degranulation – Wikipedia: https://de.m.wikipedia.org/wiki/Mastzelle

Amblyopia in old age

Effect of OPC - Amblyopia in old age

Can amblyopia in old age really be treated with OPCs? Amblyopia in old age mainly occurs when the fine capillaries in the eye are structurally no longer stable enough. Over time they become fragile and a circulatory disorder can then lead to a decreasing eyesight. Since OPCs unfold their regenerative features especially in the area of the capillaries and "seal" the tender vessel walls there, people with amblyopia in old age profit a lot form taking oligomer proanthocyanidins.

The fragility of the capillaries with amblyopia in old age is often coherent with Diabetes that results in a diabetic retinopathy in the eye. Thereby, the finest blood vessels on the retina are being damaged slowly, which can lead to loss of the patient’s sight in the long run.

Since OPC also shows a great effect with diabetes (through a positive inhibiting influence on the enzyme dipeptidyl peptidase-4 and the consequent optimization of insulin secretion), the usage of OPCs for diabetic amblyopia in old age is especially recommended.

That's why OPCs are approved in France for the treatment amblyopia in old age.

Thereby the application is based on the research of Dr. G. Maynard, who tested the efficacy with amblyopia in old age in clinical studies on 40 patients. In the first step he daily administered his patients 80 - 120mg of OPCs over a time period of one week. In the second step he reduced it to 40 - 80 mg per day, but the treatment lasted over 4 months.

90% hat less micro bleedings of their capillary vessels  thanks to OPCs and a highly increased eye sight could be observed.

In this context, the director in the university  eye clinic in Wurzburg back then compared the medicine dexium in its efficacy with OPCs. After a test period of 6 months, the results were evaluated and the effects was being rated as equivalent.

Tests of Dr. Saracco (Clinic for Ophthalmology in Marseille) have shown that OPCs can even help with the amblyopia (in old age) (hypertensive retinopathy) that is induced through blood pressure.

 

Sources:

Leydhecker, H. C. W, Universitäts-Augenklinik, Wurzburg: Wissenschaftlicher Bericht über die Effektivität und Toleranz von OPC bei der Behandlung diabetischer Retinopathie auf der Basis eines klinischen Vergleichstests.

 

Fitzpatrick et al. Endothelium-dependent vascular effects of OPC®. J Cardiovas Pharmacol 32: 509-515, 1998 and also: Belcaro G et al. Venous ulcers: microcirculatory improvement and faster healing with local use of OPC®. Angiology 56: 699-705, 2005

Alzheimer's

Effect of OPCs - Alzheimer's

How can OPC help fighting Alzheimer's - Help the illness? With Alzheimer's disease, oxidative stress plays a huge roll. That's exactly where the effect of OPCs takes place, because the oligomer proanthocyanidins are, according to professor Jacques Masquelier (the well-known OPC researcher and inventor of the OPC extraction process) the most effective antioxidants.

Since OPCs overcome the blood-cerebral barrier, the antioxidant effect is also fully present in the brain. This way, even there an ultimate protection of the brain cells from oxidative damages (that are characteristic for Alzheimer's disease) can be established and the regenerative processes are executed much better.

Especially in coherence with the fact that OPCs increase the effect of vitamin C 10-fold, it is being pointed out that for Alzheimer's disease, there should always be taken a combination of OPCs with vitamin C. The reason for that is that vitamin C itself has a strong antioxidant effect and is needed for the biosynthesis of neurotransmitters (vitamin C also overcomes the blood-cerebral barrier and unfolds its regenerative features in the brain).

The nutrient synergy complex from OPCs with vitamin C therefore directly and indirectly contributes to the improvement of the "brain chemistry", that is out of balance when it comes to Alzheimer's disease.

 

 

·        OPC+Vitamin C improves the capacity of reaction

·        OPC+Vitamin C improves the memory

·        OPC+Vitamin C improves the concentration ability
 

 

Scientists could prove in studies from the John Hopkins University that the intake of vitamin C and vitamin E lowers the risk by 78% to get Alzheimer's.  In respect of the fact that OPCs increases the effect of vitamin C and also vitamin E extremely, the usage of OPCs in combination with these antioxidants is highly recommended on patients with Alzheimer's disease.

When buying OPC products make sure that the OPC raw material was produced according to the patented procedures of the OPC inventor Prof. Jacque Masquelier and (natural) vitamin C has been added. The company which is processing it, should by all means be GMP certified in order to guarantee the necessary quality in the manufacturing process.

Take note: The less additives have been used for the OPC compound, the better it is for patients with Alzheimer's.

OPCs are also suitable for a long-term usage when it comes to the Alzheimer's disease (or even preventative) and can be administered in doses of 100 - 200mg a day.

 

Sources

 

Grape-Derived Polyphenolics Prevent A-beta Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer’s Disease“, Pasinetti, G. M., et al., Journal of Neuroscience, June 2008, Volume 28, Pages 6388-6392.

Inflammation and Nutrition, Anon. Medical Nutrition, 42-5 1989

Dr. Walter Brohmüller Scholte, BookRix-Verlag, „OPC das Super-Antioxidans.“: „Plant extract with proanthoeyainidins content as therapeutic agent having radical scavenging effect and use thereof, U.S. Patent Nr. 4.698.360 (Okt. 1987)“

Antioxidant Effect

Antioxidant effect of OPCs - How oligomer proanthocyanidins stop free radicals

As already mentioned, OPCs also have one of the strongest antioxidant effects. That means that they're especially suitable for neutralizing free radicals in the body (free radicals are aggressive oxygen compounds that can harm cells and lead to or contribute to diseases and that increase the aging process) and to principally prevent uncontrolled oxidation processes in the body.

Professor Masquelier could prove with his research in 1985 that OPCs show the strongest antioxidant effect. Thereby, other antioxidants like vitamin C, vitamin E and other bioflavonoids were compared to OPCs and Masquelier showed:

• OPCs are 18.4 times stronger than vitamin C
• OPCs are 50 times stronger than vitamin E

This way, professor Masquelier proved that OPC is the strongest natural "free radical scavenger". In the same year he registered OPCs with this features as a patent in the US, which was granted in 1987.

 

The necessity of anti-oxidation. An example for the destructive effect of "free radicals" on plasmalemma:

·        Increased aging-process.
 

·        Damage of cell membranes with free radicals (e.g. through peroxidation).
 

·        Nutrient deficiency in the cells through malfunction in the cell membrane.
 

·        "Waste disposal" from the cells doesn't work right.
 

·        The reproduction of this cell is not possible due to nutrient deficiency or because of "poisoning".
 

 

This procedure speeds up the aging process so that people in the age of 40 already have a metabolic situation and an organ quality of a person who's 60 years old, if, for example the nutrition resp. the lifestyle is "inconsistent".

Here the OPC effects apply, which especially face cell death through anti oxidation due to free radicals. Professor Masquelier discovered that mainly the short-chained proanthocyanidins, like catechin and epicatechin, and the dimeric proanthocyanidins are able to interfere with the forming of free radicals.

As already said, the capacity of the anti-oxidation of OPCs, compared to vitamin C, is about 20 times higher. But the fact that the OPCs, that were produced according to the Masquelier procedure, are able to increase the effect of vitamin C by 1000% (!!!) is just as serious.

THIS MEANS THAT THE EFFECT OF VITAMIN C THROUGHT THE SYNERGETIC EFFECT OF OPCS IS BEING INCREAED 10-FOLD!

 

This is a sensation which has no rival. In plain terms, this means that just 50mg of vitamin C in combination with approximately 100mg OPC, the effect of 500mg of vitamin C can be achieved with the nutrient synergy of vitamin C and OPCs. If one goes into the area of orthomolecular nutrient doses, it is even common to supplement up to 1000mg vitamin C. There, the anti-oxidation effect in nutrient synergy complex with OPC would be 10,000 mg vitamin C.

HEALING PROCESSES ARE USUALLY BETTER IF THE ORGANISM ISN'T ALSO ADDITIONALLY CHARGED WITH FREE RADICALS. THAT'S WHY YOU PROFIT OF THE SUPPLEMENTATION WITH OPC IN COMBINATION WITH VITAMIN C IN ALL DISEASES (when it comes to the intake of chemotherapeutics, please consult your doctor first).

So make sure that OPC is taken in combination with vitamin C (ideally natural vitamin C) if maximum anti oxidation should be achieved. Thereby it is important to pay attention to the quality of OPC - only use products that are based on the manufacturing process of professor Masquelier. If the manufacturing process was done under GMP (Good Manufacturing Practice) - this is another indication for a high quality manufacturer who spares no financial pains in order to provide his customers with the highest quality OPCs that is currently possible.

 

Sources

Sen CK, et al. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci 2002; 957: 239–49

Khanna S, et al. Dermal wound healing properties of redox-active grape seed proantho- cyanidins. Free Radic Biol Med 2002; 33(8): 1089–96

Holzhauer P et al. Prophylaxe der Chemotherapie-assoziierten oralen Mukositis

Deutsche Zeitschrift für Onkologie 2015; 47: 36–40

Condensed tannins scavenge active oxygen radicals, Uchida, Shinji, Edamastu, Rei, et.al. Med. Sci., Res., 15:831-2 (1980)

„Plant extract with a proanthocyanadins content as therapeutic agent having radical scavenging effect and use thereof, United States Patent Nr. 4.698.360 (6. Oktober 1987)“

Dr. Walter Brohmüller Scholte, Gabriele Simon & Helmut Achterath. „OPC das Super-Antioxidans.“

Arteriosclerosis

Effect of OPCs - Arteriosclerosis

OPC is also very successfully being used for arteriosclerosis. This vessel disease accumulates fatty acids, cholesterol and lime on the vessel walls whereby the blood flow is being disturbed and the elasticity of the affected blood vessel decreases. Arteriosclerosis leads to a hardening and thickening of the vessel walls and the subsequent tissue is only provided badly, or in the worst case, not at all, with oxygen. The consequence of arteriosclerosis can be an infarct - tissue dies off and vital functions could be canceled.

With arteriosclerosis OPCs interfere in a regulating way over different mechanisms with the destructive occurrences and helps to keep up the vessel quality and restores it. Probably the most important safety factor of OPCs in combination with arteriosclerosis is that the OPCs promote formation of collagen. This repairs the affected arteries and makes sure that, for example, cholesterol and lime, cannot accumulate so easily. The elasticity is also being restored due to the regeneration of the tissue, e.g. stenosis is being prevented, which is often a precursor of cardiac diseases.

OPCs also reduce the agglomeration of platelets in a natural way and thereby promote the blood flow without impairing the organism with acetylsalicylic acid through unwanted side effects.

Vessels are of course also harmed with free radicals that lead to an early cell death and prevent the reproduction of cells. Click on the link and learn more about how OPCs help to protect cells from free radicals with anti-oxidation.

 

OPCs vs. Arteriosclerosis. OPCs win on many fronts:

 

·        OPCs reduce agglomeration of platelets
 

·        OPCs repair damaged vessel walls
 

·        OPCs protect the vessel walls from deposits
 

·        OPCs bring back elasticity in the vessels
 

·        OPCs protect the vessel walls from free radicals through anti oxidation

 

Since vitamin C is highly involved in the buildup of collagen in the body and also has an antioxidant effect, it should be taken together with OPCs against arteriosclerosis and to prevent it. In this context it's noticeable that the vitamin c effect in the nutrient synergy complex with OPCs has an increased effect of 1000% -> OPCs + Vitamin C = 10  x stronger, than vitamin C alone.

Experience reports show that the daily intake of up to 400mg of OPCs (ideally extracted according to the Masquelier technique) in combination with vitamin C for 4 months and a subsequent intake of 300mg for 3 months, as well as another long-term supplementation of 200mg a day show severe improvements of the quality of the vessel walls. (Source: Anne Simons, Das OPC Arbeitsbuch, „Fallbeispiel Herzinfarkt – Ablagerungen in der Aorta“, Maya Media Verlag, 2013).

So if you want to prevent or reduce arteriosclerosis, you can take a big step into the right direction with OPCs in combination with vitamin C.  Thereby you should pay attention to the quality of the compound by all means and do not get blinded by cheap offers. The OPC product should be manufactured under GMP requirements, contain the French Masquelier raw material (pine bark and/or grape seed extract) and, ideally, even include natural vitamin C already in order to ensure an optimal nutrient synergy.

 

Sources

Hosseini et al., „A randomized, double-blind, placebo controlled, prospective 16 weeks crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patients; Nutr Res 21(9):67-76, 2001

Cholesterol and foam cell control with OPC: The atherosclerotic antidote White, David, Internationale Konferenz der OPCforschung, Bordeaux, Frankreich (4.-6. Oktober 1990)

Belcaro G, Cesarone MR, Rohdewald P, et al. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost. 2004;10(4):373-377

Condensed tannins scavenge active free radicals. Uchida, S. et al., Med. Sci. Res. 15:831-2 (1987)

Eine neue Therapie für Venenkrankheiten, Feine-Haake, G., Zeitschrift für Allgemeinmedizin, 51:7, 839

Protective effect of wine in laboratory animals fed a cholesterol-enriched diet. FayMorgan, A., Brinner, L., Plaa, C.B. und Stone, M.M., Amer. J. Physiol. 189:290 (1957)

i.a. Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res. 2002;16 Suppl 1:S1-5.

Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine. 2000;7(5):383-388

Arcangeli P. Pycnogenol in chronic venous insufficiency. Fitoterapia. 2000;71(3):236-244

Anti-Aging

Effect of OPC - Anti-Aging

Among others, OPCs are one of the most potent anti-aging nature substances that are available at the moment. This is mainly due to the fact, that anti-aging is characterized by the body being in the situation to optimally eliminate free radicals in the body. Exactly that is the specialty of oligomer proanthocyanidins (OPCs), which have a preventive and a directly regenerative effect to fight free radicals more effectively than any other substance.

With this "inner" anti-aging aspect, OPCs directly influence the longevity and health of the cell. Because the evacuation of cell toxins, as well as the storage of vital nutrients and vital materials is being improved with OPCs. Besides this effect on the cell longevity, OPCs are also able to discover degenerated cells and to stop their growth and spreading, yes and even cause their decay.

Probably the optically most astounding aspect of anti-aging in the context of the intake of OPCs lies in the skin quality of the user. After some time, an enormous improvement can be observed in skin elasticity, smoothness and tightness (sometimes even after just a few days). The reason for that is elastin (a fiber protein, which is responsible for the elasticity of the tissue) is structurally closely related with collagen and profits a lot from OPC nourishment. Alone the renewal and revitalization of elastin and collagen starts a process in the entire body that really deserves the term anti-aging.

OPCs are anti-aging par excellence

OPCs - reduce free radicals, which are the main cause for quick aging.

OPCs - optimize the nutrient transportation in the cells.

OPCs - improve the removal of toxins from the cells.

OPCs - fight degenerated cells.

OPCs - helps with better blood circulation in the skin (=> optimal nutrient  supply in the skin).

OPCs - help for a much younger looking skin.

OPCs - reduce an excess of melanin formation and thereby the amount of age marks.

OPCs - regenerate collagen and elastin in the entire body.

 

This is just an excerpt of the obvious effects of OPCs for anti-aging  purposes. In our opinion, OPCs are one of the few natural substances that can actually visually contribute to one of the oldest goals (anti-aging) of humanity.

 

INNER AND OUTER BEAUTY

For a quicker improvement of the skin quality for example you can take 400 mg of OPCs / day that you should combine with vitamin C (at least 80 mg / day), in order to increase the effect on the elastin / collagen regeneration. After that an anti-aging maintenance dose of about 100 mg of OPCs / day, in order to regenerate and protect your skin and the entire tissue of your body.

 

Sources:

Yasumuro M et al. Inhibition of melanogenesis by pine (Pinus pinaster) bark extract containing procyanidins. Manuscript in preparation 2006

Evidence by in vivo and in vitro studies that binding of OPC to elastin affects its rate of degratation by elastases; Tixier, J.M., Godeau, G., Robert, A.M. und Homebeck, W., Biochem. Phartnacol., 33(24) 3933-9 (1984)

Stabilisation du collagene par des oligomeres procyanidoliques; Acta Therapeutica 7:101-5 (1981).

Hughes-Formelia B., Wunderlich O., et al., „Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins.“;Skin Pharmacol Physiol. 2007;20(1):43-9. Epub 2006 Oct 11

Buonocore D., Lazzaretti A., Tocabens P et al., „Resveratol-Procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo controlled, double blind study.“ Clin Cosmet Invest Dermatol 2012, 5: 159-165

Asthma

Effect of OPCs - Asthma

What effect does the intake of OPC have on asthma? There are some interesting studies on that subject which prove that OPCs can help reduce the medication that is being used with asthma, as well as to improve the symptoms.

The most stunning result can be seen in the study  Asthma. 2004;41(8):825-32.Pycnogenol as an adjunct in the management of childhood asthma; Lau BH1, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA.

In this randomized, placebo-controlled double-blind study with 60 test subjects at the age of 6 - 18 years, the effect of OPCs (oligomer proanthocyanidins) were tested over a time period of 3 months for light up to moderate asthma. After the baseline analysis the test subjects were randomized into two groups, whereby the one group got OPCs and the other got a placebo.

The test subjects were told to record the result every evening with a peak flow meter. They also should record asthma symptoms, the daily usage of inhalators (albuterol), as well as every change of the oral medication. In regular intervals, urine samples were provided in order to measure leukotriene C4, D4 and E4. Leukotriene are inflammation mediators that increase the production of mucus, and are co-responsible for a strained musculature of the upper airways and the bronchia.

After evaluating the study they found out that the OPC group had a better lung function and that the asthma symptoms declined. The usage of the inhalator could be reduced in the OPC group and even stopped entirely in some cases and this in a significantly higher extent than in the placebo group. A very clear decrease of leukotrienes in the OPC group showed that the asthma inflammation mediators could be tackled brilliantly with OPCs.

After 3 months, a better breathing volume from 70% to 87% could be measured in the OPC group.

Other OPC studies with grown-ups showed similar results in regards to the improvement of the breathing performance with asthma, but were only conducted too shortly in order to gain a statistically significance / relevance.

Summary OPCs vs. Asthma:

 

1.     OPCs help to reduce the leukotrienes with asthma.
 

2.     OPCs help to improve the breathing volume with asthma.
 

3.     OPCs help to minimize the inhalator usage of asthma.
 

4.     OPCs help to reduce / relieve the symptoms of asthma.
 

 

If you have asthma, start with a daily administration of 1mg OPCs / kg bodyweight over a time period of 1 month and if necessary, increase the dose up to 2 mg OPCs / kg bodyweight, if the results are not yet according to your ideas.

 

 

Sources

 

Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 2004;41(8):825-832.

Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR. Pycnogenol in the Management of Asthma. J Med Food. 2001;4(4):201- 209

Eyes

Effect of OPCs - Eyes

OPCs are also very useful for the eyes in order to increase the speed of healing processes. A lot of eye diseases or sight problems are due to the free radicals that attack collagenous fiber in the eye. Here, OPCs work as radical scavengers and eliminate these harmful oxygen compounds.

OPCs also help to repair damages from free radicals by, for example, repairing the collagenous fiber on the retina. By doing that alone, OPCs contribute to not encourage the eye disease cataract.

Other eye diseases like pinkeye profit from OPCs, because the oligomer proanthocyanidins reduce inflammation mediators resp. help so that they are not produced and distributed in a high dose. On top of that, OPCs are known that they play an important role when it comes to repairing the finest capillaries (also in the eyes of course!), by restoring the vessel walls of these small blood vessels in their collagen structure.

This way, the circulation of the eyes is being improved again and nutrients can access the cells better. On the other hand the removal of metabolism-residue is optimized with OPCs and therefore the indirect damage of the health of the eyes is being prevented.

OPCs help your eyes

 

·        OPCs reduce inflammation in the eyes.
 

·        OPCs improve the circulation in the eyes.
 

·        OPCs optimize the nutrient transport in the eyes.
 

·        OPCs eliminate free radicals in the eyes.
 

·        OPCs help repair the collagenous fire in the eyes.
 

 

Depending on the severity of the eye disease, take up to 3 mg / kg bodyweight OPCs a day until you see an improvement and then reduce the daily intake to 1 - 2 mg / kg bodyweight per day as a maintenance dose.

Sources:

Condensed tannins scavenge active free radicals, Uchida, S. et al., Med. Sci. Res. 15:831-2

Hosseini et al., A randomized, double-blind, placebo controlled, prospective 16 weeks crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patients; Nutr Res 21(9):67-76, 2001

Wissenschaftlicher Bericht über die Effektivität und Toleranz von OPC bei der Behandlung diabetischer Retinopathie auf der Basis eines klinischen Vergleichstests, Leydhecker, H. C. W, Universitäts-Augenklinik, Wurzburg

Stabilisation du collagene par des oligomeres procyanidoliques, Acta Therapeutica 7:101-5

Dryness of the eyes

Effect of OPCs - Dryness of the Eyes

Can OPCs also help with dry eyes? Especially nowadays dry eyes are a big problem since people spent a lot of time in front of screens and more and more rooms are air-conditioned. By working very concentrated in front of the monitor or watching TV nonstop, the eye can be heavily overloaded which can also lead to dryness of the eye (of course this also depends on the nutrition, intake of fluids and vital substance  supply). A reason for this kind of eye dryness can be, that the blinking frequency is being reduced and thereby the eyelid cannot distribute the tear fluid as often on the surface of the eye.

The impact of air-conditioned room air on the dryness of the eyes is totally different. As you already know, the room air gets unnaturally dry with air conditioners. Thereby the humidity is extremely decreased, depending on the strength and the duration of the air-conditioning. In this surroundings, the room air downright absorbs the humidity from the air like a dry sponge - this also affects objects as well as natural biological bodies. That's why humans, animals, as well as plants suffer from air-conditioning. So in this case, dryness of the eyes is an "evaporation problem".

Most people however don't know, that with overload and air-conditioning an impairment of the lacrymal gland can occur up to an inflammation. This in return leads to decreased lacrimal fluid production. In this case, the dryness of the eye comes from an inflammation that can usually be treated outstandingly with OPCs.

If one is always exposed to above mentioned conditions, OPCs can also help with the prevention of chronic dry eyes (that come about the already mentioned inflammation in the lacrymal glands).

Besides these mentioned causes for eye dryness, a poor composition of the tear liquid can make the tear film on the eye evaporate too quick. The reason for that is, that the tear fluid is also composed of lipids, fats, that are responsible to keep the liquid tear fluid components on the eye surface long enough. With oxidative procedures / free radicals these lipids are harmed, which negatively affects this "moist keeping feature" of the tear liquid. Free radicals can actively be tackled with OPCs and oxidative damages can be prevented.

For that we recommend a daily intake of OPCs of at least 1 mg per kg bodyweight. If an acute or chronic inflammation already exists, you can take 2 - 3 mg of OPCs per kg bodyweight until there's an improvement in with eye dryness. Then you can lower the intake to the mentioned 1 mg / kg / day.

Sources

Ernst-Albert Meyer, PTA-Forum Pharmazeutische Zeitung, Artikel: Das trockene Auge – die Lipidschicht wird geschädigt. Pta-forum.de

 

Inflammation and Nutrition, Anon. Medical Nutrition, 42-5 (1989)

 

Olenik, A., et al., „Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study“, Clinical Ophthalmology, 2014, Volume 8, Pages 169-176

Legs

Effects of OPCs - Legs

Many people know the problem, that the legs are swollen in the afternoon or evening and that they feel heavy. This can be a sign of vessel weakness where liquid comes out of the lymph vessels and collects in the tissue of the legs. The consequence of this could be feelings of heaviness and pressure that are not uncommonly linked to pain in the legs.

The flavons in the OPCs are known for helping with the repair of porous vessel walls. This process is being activated by repairing the "fragile" collagen structures in  the vessel walls of the legs with the short-chained compounds of the OPCs.  Subsequently the vessels are leak-proof again and the danger of depositions of fluids / edema formation in the tissue of the legs decreases significantly.

This problem is especially known with "frequent fliers" who do not only suffer from edema formations due to the pressure changes, but also in the worst case with thrombosis. This way platelet adherences can disturb the blood flow in the legs so much that the tissue cannot be supplied with blood any longer. Thrombosis can be life threatening and one should do everything that is possible to not develop it further.

OPCs help to prevent thrombosis in the legs in the first place by optimizing the blood flow in many ways. An anecdote from the life of the OPC inventor Professor Jacques Masquelier fits perfectly here. The wife of his doctoral adviser was suffering from edemata and was being treated with OPCs that back then were still extracted from peanut skins (that people usually don't like). Only two days later, the edemata were gone and this is how this nice lady was the first test subject for OPCs in regards to its vessel sealing effect of the oligomer proanthocyanidins.

OPCs - the ideal help for burdened legs:

 

·        OPCs fight the development of thrombosis.
 

·        OPCs help reduce the vessel permeability.
 

·        OPCs optimize the blood flow in many ways.
 

·        OPCs reduce free radicals that are involved in damage of the vessels.
 

·        OPCs are successfully used against edemata / deposition of fluid in the legs.
 

In order to fight acute edemata or heaviness of the legs (or other extremities) use 2 - 3 mg OPCs per kilogram bodyweight / day. For the prophylaxis of thrombosis and edemata formation, 1 - 2 mg of OPCs / kg bodyweight / day should be enough.

 

Sources:

Belcaro G, Cesarone MR, Rohdewald P, et al. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost. 2004;10(4):373-377

Natürliche Produkte als medizinische Wirkstoffe, Beal, J.L. (ed.), Hippokrates Verlag, Stuttgart (1980)

Oedema-inhibiting effect of procyanidin, Blazso, G. und Gabor, M., Acta Physiologica Scientiarum Hungaricae, Tomus 56(2) 235-40, 1980

Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res. 2002;16 Suppl 1:S1-5.

Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine. 2000;7(5):383-388

Arcangeli P. Pycnogenol in chronic venous insufficiency. Fitoterapia. 2000;71(3):236-244

Fascia

Effect of OPCs - Fascia

 

The conjunctive tissue consists mostly of collagen fiber and has many tasks in the body. Since of the main features of OPCs is to repair collagenous structures, the human conjunctive tissue (but also the one of animals) profits  from a supplementation with OPCs (oligomer proanthocyanidins that are ideally extracted  and manufactured from grape seeds and/or pine bark)

 

Like hardly no other nutrient the components of OPCs are stored exactly in the "ladder" of the conjunctive tissue (in the collagenous fiber to be exact) where the rungs, so to speak, are broken. The OPCs fit perfectly into these breakpoints and restore again the necessary tone, elasticity and stability.

 

This storage effect happens due to the protein affinity of OPCs - it tends to stick itself to proteins. Since the fascia / collagen consist of proteins, the effect is especially high in this area.

 

Apart from the repair of the damaged parts of the conjunctive tissue with OPCs, the features as an antioxidant resp. as a radical scavenger is effective due to the adherence of OPCs to the collagenous protein of the conjunctive tissue. That means for the conjunctive tissue that already with the first intake of OPCs, the tissue is protected from free radicals and thereby from early aging.

 

Thereby it is very important, in my opinion, that the right OPCs are chosen, which were produced according to the standards of the OPC inventor Prof. Jacques Masquelier. Only this way it can be ensured that the effects that one is hoping for are achieved by taking OPCs.

 

Vitamin C also makes a significant contribution to the buildup of collagen in the body and that's why it immediately suggests itself that vitamin C is taken together with OPCs in order to regenerate and to protect the conjunctive tissue. This especially makes sense, since joined intake of OPCs and vitamin C increases the effect of vitamin C 10-fold (=1000%!!! ). That means that by only taking 100 mg of vitamin C, the effect of 1000 mg of vitamin C can be achieved - that's a reason to celebrate for the novice in orthomolecular medicine.

 

OPCs can help here with its positive influence on the conjunctive tissue:

 

·        OPCs help with gingival recession.

·        OPCs help with the healing of scars.

·        OPCs help with cellulitis.

·        OPCs help to improve the elasticity of the skin.

·        OPCs help to fight bone loss.

·        OPCs help to reduce stretch marks.

·        OPCs help against muscle loss.

·        OPCs help with tissue repair, bone healing and the healing of the tendons.

·        OPCs helps to remove edemata, resp. to prevent them.

 

Just by taking 1 - 2 mg OPCs / day / kg bodyweight you can perfectly nourish your conjunctive tissue. Especially if you also take vitamin C with it, so that an optimal nutrient synergy complex is being created. Please don't be impatient - OPCs can already start working after just a few days, but its full effect is seen if you constantly supplement it for at least 3 months. The combination of vitamin C and OPCs is, according to my experience, one of the best long-term food supplements and according to decades of research by Prof. Masquelier free of any side effects.

 

Sources:

 

Grimm T et al. „Antioxidant activity and inhibition of matrix-metalloproteinases by metabolites of maritime pine bark extract (Pycnogenol®).“ Free Rad Biol Med 36: 811-822, 2004

 

Collagen treated with catechin becomes resistance to the action of mammalian collagenase Kuttan, R., Donnely, Patricia V. and Di Ferrante, N, Experientia 3 7 (1981)

 

Evidence by in vivo and in vitro studies that binding of OPC to elastin affects its rate of degratation by elastases, Tixier, J.M., Godeau, G., Robert, A.M. und Homebeck, W., Biochem. Pharmacol., 33(24) 3933-9 (1984)

 

Segger D, Schönlau F.,, „Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women.“, J Dermatol Treat 15: 222-226, 2004

 

Oedema-inhibiting effect of procyanidin, Blazso, G. und Gabor, M., Acta Physiologica Scientiarum Hungaricae, Tomus 56(2) 235-40 (1980)

Pinkeye

Effect of OPCs - Pinkeye

 

A very widely spread eye disease that almost everybody suffered from at some point in their lives is pinkeye. Even here, OPCs can be taken with great success, since almost all causes for pinkeye and the respective symptoms can be fought off perfectly with OPCs.

Pinkeye, that is also known under the term conjunctivitis, can have many causes, whereby the symptoms are almost always the same.

 

Causes for pinkeye that can be fought off with OPCs:

 

·        Allergically induced causes (e.g. conjunctivitis allergica / vernalis).

·        Bacterial (e.g. through unspecified coccal).

·        Mechanically induced causes (e.g. dry and acute conjunctivitis).

·        viral infections, fungi or parasites.

 

As already mentioned, the symptoms are almost always the same when it comes to pinkeye and is expressed in a heavily bleed-through and reddened conjunctiva. Thereby the conjunctiva can also swell, the lid slit can narrow, the feeling of a foreign body can occur (maybe combined with an itch or severe biting) and a certain photophobia can befall the affected people in the acute and of course in the chronic phase.

 

OPCs help to seal the vessels and, since this characteristic takes especially effect in the capillaries, swellings on the eye, that are caused by pinkeye, can easily be treated. Even the redness of the eyes and the inflammation of the capillary vessels on the conjunctiva, can easier be subside with the help of OPCs.

 

Since an optimal functioning immune system is of course quicker / more effective when it comes to infections, the OPCs are already helping to heal pinkeye quicker on a meta level. The reason for that is that OPCs are the strongest known antioxidant and fights off free radicals better than any other nutrient. This way, the immune system has the full load output at its disposal in order to fight acute pinkeye.

 

OPCs also increase (even while having pinkeye) the effect of other vitamins, like vitamin C and E 10-fold, which creates a unique immune boost on the basis of a powerful nutrient synergy.

Since OPCs can also halt inflammation mediators like histamine, the symptoms of pinkeye that are caused by an histamine reaction, are also perfectly responded to by the targeted use of the oligomer proanthocyanidins.

 

OPCs help with pinkeye by:

 

·        reducing the inflammation mediators of pinkeye.

·        repairing the affected capillaries of pinkeye.

·        helping against swellings of pinkeye.

·        strengthening the immune system even during pinkeye.

·        helping the removal of cell waste materials of pinkeye.

·        contributing to a better nutrient supply of the affected cells of pinkeye.

 

The recommendation of the intake of OPCs for pinkeye refer to experience and lies at 1 - 2 mg OPCs / kg bodyweight per day. It's also not bad if the dose is increased to 2 - 3 mg OPCs / kg / day for a short amount of time, if the symptoms are severe. For pinkeye I also always recommend to take a compound which, next to the OPCs also contains vitamin C (collagen repair of the capillary vessels, immune system, antioxid stress, etc.)

 

Sources:

 

Wissenschaftlicher Bericht über die Effektivität und Toleranz von OPC bei der Behandlung diabetischer Retinopathie auf der Basis eines klinischen Vergleichstests, Leydhecker, H. C. W, Universitäts-Augenklinik, Wurzburg.

 

Hughes-Formelia B., Wunderlich O., et al., Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins.;Skin Pharmacol Physiol. 2007;20(1):43-9. Epub 2006 Oct 11

 

Jerez et al., „A comparison between bark extracts from Pinus pinaster and Pinus radiata: Antioxidant activity and procyanidin composition“; 2005; DOI: 10.1016/j.foodchem.2005.09.064

 

Inflammation and Nutrition, Anon. Medical Nutrition, 42-5 (1989)

 

J Med Food. 2003 Winter;6(4):291-9. Polyphenolics in grape seeds-biochemistry and functionality. Shi J, Yu J, Pohorly JE, Kakuda Y. Food Research Center, Agriculture and Agri-Food Canada, Guelph, Canada.

Blood viscosity

Effect of OPCs - Blood viscosity

The blood viscosity is an important factor in terms of cardiovascular health. The term blood viscosity describes the flow features of blood, the higher the blood viscosity, the thicker is the blood and the worse it is for the cardiovascular system. With increasing blood viscosity, the risk of a thrombosis formation increases.

 

Since OPCs help to lower the thrombocyte aggregation as well as cholesterol levels, the OPCs actively play an active part in reducing the blood viscosity. The collagenous regenerative, antioxdiative and anti-inflammatory effects of OPCs have very positive perspectives involved.

 

OPCs reduce blood viscosity and:

 

·        Lower the danger of forming a thrombosis.

·        Lower the risk of getting arteriosclerosis.

·        Lower the risk of forming edemata.

·        Lower the danger of an infarct.

·        Lower the LDL levels (bad cholesterol) by increasing the HDL level (good cholesterol).


The fact that OPCs are able to optimize blood levels by increasing the good HDL (high density lipoprotein) is very interesting. By using OPCs the HDL level in the blood increases and the LDL level decreases which can be seen very well in this graphic:

 

HDL transports fats (also the "harmful" LDL) back to the liver where they are degraded and LDL transports fats into the blood circulation. The less LDL is in the blood circulation the lower the blood viscosity is as well -> the blood flows better / is thinner. The dangers for cardiovascular diseases decrease therefore with low blood viscosity because of the positive influence of the OPCs on the good HDL.  But one should always keep in mind that it's important that LDL should be protected from an excessive oxidation, because a cascade of unhealthy processes can be started with oxidized LDL. So it's good to know that OPCs also protect LDL from oxidation.

 

The studies for that have been conducted with the French pine bark extract from professor Masquelier.

 

Also for the blood viscosity I recommend the dose of 1 - 2 mg OPCs / kg bodyweight for preventive purposes and in acute cases a higher intake of 2 - 3 mg / kg / day until the laboratory findings / symptoms get better.

Sources

 

Tebib K, Bessanicon P, Rouanet J. Dietary grape seed tannins affect lipoproteins, lipoproteinlipases, and tissue lipids in rats fed hypercholesterolemic diets. J Nutr 1994;124:2451-2457.

 

Wegrowski J, Robert AM, Moczar M. The effect of procyanidolic oligomers on the composition of normal and hypercholesterolemic rabbit aortas. Biochem Pharmacol 1984;33:3491-3497.

 

Rouanet, J.-M (2002); Etude de l’effet de l’oligopin sur la surface des dépôts lipidiques chez le hamster doré syrien, Unité de nutrition-Génie Biologique et Science des Aliments - Université de Montpellier

Blood levels

Effect of OPCs - Blood levels

 It is well known that with the blood levels of a human being one can draw conclusions to the state of health. That's the reason why the blood levels are one of the most common foundation of diagnosis of a doctor. Thereby one of course shouldn't forget that every human being has his or her own metabolism and that the blood levels as well need to be viewed under individual aspects. Nonetheless there are standard values and limit values that enable the doctor to examine further in a certain direction in order to, for example, find out the causes of  symptoms of a disease easier. This way, one can see the blood levels as coordinates on the "health map" that enable the doctor to limit the "diseased area" better, in order to find the ideal way of healing this area.

 

OPCs can help with bringing back blood values to the standard value when they get out of control. The big advantage of OPCs thereby is, that they do not only provide symptomatic remedy, but also get down to the sick root of the trouble.

 

The two "classic" blood levels, that can be respectively "treated" with OPCs are blood sugar levels on the one hand and blood fat values on the other. According to studies of blood sugar levels, the OPCs can modulate the insulin secretion in a way, so that the insulin release is only then increased if food is really ingested. For the blood fat levels, an increase of the HDL levels could be accomplished, while the LDL blood levels were reduced according to studies with OPCs form pine bark extract..

 

When it comes to the treatment of diseases one aspect becomes more and more important and that's the health of the intestine. There are also blood levels that well trained doctors take into consideration in order to draw their conclusion about resp. from the reactions of the body. The blood value that is being looked at especially when it comes to allergic reactions is the calprotectin level. With these blood levels one can draw conclusions about the intestinal density - the higher the Calprotectin - blood level is the bigger is the danger for the so-called leaky-gut-syndrome (leaking intestines)

 

All in all OPCs help  to bring back the blood levels into normal range by helping to eliminate free radicals better than any other nutrient as the strongest known antioxidant . Since free radicals are often the cause of a shift in the blood levels, by negatively influencing the metabolism processes, a permanent reduction of these "aggressors" alone can help improve the blood levels with OPCs.

 

With a permanent supplementation of 1 - 2 mg OPCs (if one has extreme deviations this can also be increased to 2 - 3 mg) / kg bodyweight / day an optimization of the blood levels can perfectly be supported. Of course I do not recommend to take OPCs alone. If blood levels get out of hand, your doctor will take necessary therapeutic action in order to help you.

 

 

Sources:

 

Chronic administration of dietary grape seed extract increases colonic expression of gut tight junction protein occludin and reduces fecal calprotectin: a secondary analysis of healthy Wistar Furth rats; By Goodrich, Katheryn M.; Fundaro, Gabrielle; Griffin, Laura E.; Grant, Ar'Quette; Hulver, Matthew W.; Ponder, Monica A.; Neilson, Andrew P.

From Nutrition Research (New York, NY, United States) (2012), 32(10), 787-794. Language: English, Database: CAPLUS, DOI:10.1016/j.nutres.2012.09.004

 

Grape Seed-Derived Procyanidins Decrease Dipeptidyl-peptidase 4 Activity and Expression

Noemi Gonzaĺez-Abuín, Neus Martínez-Micaelo, Mayte Blay, Gerard Pujadas, Santiago Garcia-Vallve,́ Montserrat Pinent, and Anna Ardev́ol; Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Tarragona, Spain

 

Chiva-Blanch G., et al.; „Effects of Red wine polyphenols and alcohol on glucose metabolism an the lipid profile: a randomized clinical trial“; Clinical Nutrition Volume 32, Issue 2 , Pages 200-206, April 2013

Bronchitis

Effect of OPCs - Bronchitis

As it is common for a ...itis, the bronchitis as well is an inflammation of tissue. In the case of bronchitis, the air airways of the lungs are sore. Depending on the course one distinguishes between acute and chronic bronchitis, whereby the chronic bronchitis is clearly defined according to WHO:

 

One talks about chronic bronchitis when there's coughing and phlegm on most days on at least three months in two successive years.

 

The causes of bronchitis are diverse. Viruses, as well as bacteria can lead to an inflammation of the bronchia and even allergic reactions can be seen with bronchitis.

 

Since OPCs can fight off inflammations as well as have an regenerative effect on affected tissue, they can also perfectly help for bronchitis - no matter if it's acute or chronic.

 

On top of that, OPCs help to support the immune system during a bronchitis by reducing free radicals which also always play a part in inflammation processes. The less work the immune system has with free radicals the more defense potential is available in order to fight off the causes of bronchitis.

 

OPCs help with bronchitis in many ways:

 

·        reduce inflammation emergences.

·        improve the removal of metabolic "scum".

·        optimize the nutrient supply of the cells.

·        fight off the free radicals, have an antioxidant effect.

·        strengthen the immune system.

·        help with the regeneration of the lung tissue.

·        improve the circulation of the lung.

 

The usual OPCs  dose of 1 - 2 mg OPCs / kg bodyweight / day can also support the healing process of bronchitis and can be increased to 2 - 3 mg / kg if necessary.

 

Sources:

 

Schutz, K.; et al; „Immune-modulating efficacy of a polyphenol-rich beverage on symptoms associated with the common cold: a double-blind, randomised, placebo-controlled, multi-centric clinical study“; British Journal of Nutrition; Epub published ahead of print doi:10.1017/S0007114510002047

 

Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 2004;41(8):825-832

 

Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR. Pycnogenol in the Management of Asthma. J Med Food. 2001;4(4):201- 209.

 

Wilson D, Evans M, Guthrie N, Sharma P, Baisley J, Schonlau F, Burki C; „A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms.“;Phytother Res. 2010 Aug;24(8):1115-9. doi: 10.1002/ptr.3232

Cellulite

Effect of OPCs - Cellulite

Cellutlite is also known under the term orang-peel skin and is the definition of a change in the subcutis tissue. Mainly the part of the thighs and the bottom are affected by cellulite, whereby the pockets of the orange-peel skin can be seen that look like orange peel.  Mainly women are affected by cellulite, since men have a different metabolism. As a side note I want to mention that the term cellulitis, which if often used for this symptom, is wrong. Other than cellulitis, cellulite is not an inflammatory change of the subcutis and can therefore be clearly distinguished.

 

The cellulite is being caused by a light lymph congestion in the subcutis fat tissue. Thereby the collagenous strands of the fascia more or less swell. When this happens, the upper part of the skin shows a small cushioning and most women (and sometimes even men) think it's unattractive. Since cellulite can often even appear at a young age (for hormonal reasons) this can also bring enormous psychological problems to young women.

 

When the "basic conditions" for cellulite are given and on top of that free radicals heavily burden the metabolism, the cellulite can develop to cellulitis. Thereby the tissue gets inflamed - in this case through the oxidation of fats in the subcutis.

 

OPCs already help prevent cellulite beforehand and counteracts it, by avoiding swelling and lymph congestions. With OPCs an optimization of the collagenous structure is being achieved whereby the risk of a swelling sinks. At the same time, the tissue of cellulite is better supplied with blood and the lymph fluid can flow off easier with the help of OPCs.  If one already has cellulitis, OPCs help to better heal the inflammation and reduces inflammation symptoms.

 

OPCs helps in many ways for cellulite:

 

OPCs improve the blood flow.

OPCs OPCs - regenerate collagen and makes the entire body more elastic.

OPCs reduce waste materials.

OPCs improve the nutrient supply of the cells.

OPCs help reduce swellings.

OPCs reduce inflammations.

 

In order to prevent or to counteract already existing cellulite, you can take 2 mg OPCs / kg bodyweight per day. If an inflammation occurs you can also take 3 - 4 mg OPCs / kg bodyweight per day until the inflammation subsides. Since OPCs did not show side effects even when it's taken in higher doses, "pulse cures" could be helpful, whereby 1 - 3 mg / kg / day should be totally enough in order to get a lasting effect. Thereby one should also be patient according to the form of the symptoms, since OPCs do not only fight off the symptoms of cellulite but also begin etiologically and bring lasting results.

 

Here it also makes sense to take vitamin C (min. daily amount of 80 mg) together with OPCs due to the desired effect on the collagenous tissue, because vitamin C is a part of all collagen buildup processes in the body. OPCs strengthen the effect of vitamin C by 1000%!!!

 

 

Sources:

 

M. Aoun, F. Michel et al.; „A grape polyphenol extract modulates muscle membrane fatty acids composition and lipid metabolism in high-fat-sucrose diet-fed rats“; British Journal of Nutrition; Published ahead of print doi:10.1017/S0007114511000602

 

Nicole Ronsard: Cellulite: those lumps, bumps, and bulges you couldn't lose before. Beauty & Health Pub. Corp., 1973. (Quelle: Wiki)

 

Sang Min Kim, Suk-Woo Kang, Je-Seung Jeon and Byung-Hun Um, „A comparison of Pycnogenol® and bark extracts from Pinus thunbergii and Pinus densiflora: Extractability, antioxidant activity and proanthocyanidin composition“, Journal of Medicinal Plants Research Vol. 6(14), pp. 2839-2849, 16 April, 2012

 

Hughes-Formelia B., Wunderlich O., et al., „Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins.“;Skin Pharmacol Physiol. 2007;20(1):43-9. Epub 2006 Oct 11.

 

Buonocore D., Lazzaretti A., Tocabens P et al., „Resveratol-Procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo controlled, double blind study.“ Clin Cosmet Invest Dermatol 2012, 5: 159-165

Cholesterol

Effect of OPCs - Cholesterol

 

Cholesterol is a vital endogenous substance that is being produced by every human being himself. Contrary to the common opinion, cholesterol is NOT fat, but a sterol - so a steroid pre-stage from which a huge amount of follow-up substances are built up in the body.

 

Cholesterol is produced by the body for:

·        Hormone production

·        Buildup of the plasma membrane

·        Transport of signal substances in the cells

·        Production of vitamin D (together with light)

and much more.

 

Since cholesterol is not water-soluble, it is being transported in so-called lipoproteins in the blood plasma. The most well-known are HDL and LDL.

 

The lipoproteins LDL transport cholesterol from the liver into the tissue.

The lipoproteins HDL transport cholesterol back to the liver.

 

Since these lipoproteins do not only transport cholesterol but also fatty acids and other substances, the lipoproteins connect fatty acids and cholesterol (so-called esterification). Maybe that's where the misbelief comes from that cholesterol is fat.

 

Cholesterol is extremely prone to oxidation processes from which very harmful metabolic reaction products can arise. With certain metabolic situations it can occur that the cholesterol level is high which can then subsequently lead to the following problems:

 

·        Cardiovascular problems

·        Vessel problems like arteriosclerosis

·        Gall stones

 

With OPCs the "good" HDL levels in the blood increase and the "bad" LDL level decrease, whereby the plaque formation should be reduced. Also an excessive oxidation of cholesterol is being prevented which is happening due to the extremely strong antioxidant features of OPCs.

 

OPCs have many positive effects in regards to cholesterol:

 

OPCs help to optimize the cholesterol level.

OPCs protect cholesterol from massive oxidation.

OPCs reduce the formation of gall stones.

OPCs fight active arteriosclerosis.

OPCs help dismantle "waste material"

 

 

In order to optimize the cholesterol levels, you should at least take 1 mg of OPCs / kg bodyweight per day (in practice you will not need more than 4 mg / kg bodyweight per day as long-term supplementation in order to achieve a long lasting effect.).

 

 

Sources:

 

Hans-Jürgen Holtmeier: Cholesterin, Zur Physiologie, Pathophysiologie und Klinik. Springer, Berlin 1996. ISBN 3-540-60671-8

 

Robinson, M., et al., Effect of Grape Seed Extract on Blood Pressure in Subjects with Pre-Hypertension, Journal of Pharmacy and Nutrition Sciences, Volume 2

 

Edirisinghe, I., et al., Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome;  randomized, crossover, placebocontrolled study, Functional Foods in Health and Disease, Volume 2, Issue 12

 

Wikipedia: https://de.m.wikipedia.org/wiki/Cholesterin

 

Cholesterol and foam cell control with OPC: The atherosclerotic antidote, White, David, Internationale Konferenz der OPCforschung, Bordeaux, Frankreich (Oktober 1990)

Bowel Cancer

Effects of OPCs - Bowel Cancer

 

According to Wikipedia, bowel cancer is the second most common form of cancer that German men and women get. Thereby the number of people who get bowel cancer is relatively high with 6% nationwide. Most times bowel cancer arises from initially innocent polyps that can "degenerate" over time.

 

Since the number of people with bowel cancer is very high, especially at an older age, the health insurance companies pay an enteroscopy starting from the age of 55 within the scope of a so-called preventative coloscopy (once every 10 years). Are there, however, "suspicious facts" or symptoms for such a disease that do not allow a clear diagnosis (extreme diarrhea, prolonged digestive problems, pain, blood in the stool etc.) the doctor can set out a coloscopy where they of course always check if there are any signs for bowel cancer.  This way, one does not need to wait until the age of 55 or until the next 10 years are over.

 

According to the Professional Organization of German Internists, bowel cancer often develops without noticeable causes. But they say there are two main risk factors.

 

Bowel cancer and its two main risk factors:

 

·        Significant factors increase the risk of getting the disease.

·        An unhealthy lifestyle increases the risk to get the disease.

 

 

One has to ask - who in my family already got bowel cancer and how is my lifestyle?

 

I urgently recommend to do the preventative coloscopy when there are any risk factors for bowel cancer.

 

Considering that an unhealthy lifestyle is one of the two main risk factors for bowel cancer, it is very important to take a look at one’s own unhealthy aspects of life and to exchange them as far as possible with healthier measures. This would be logical anyway.

 

In this relation it is almost a sensation what a Korean research team of the Hanseo University / Seosan in South Korea already made public about bowel cancer in the year 2005.

 

The research team of Dr. Young-Jung Kim experimented with a bowel cancer cell line with the name SNU-C4 that has been treated with OPC throughout the experiment. Thereby the researchers found out that OPCs have a so-called apoptotic effect on these colorectal SNU-C4 cell lines. That means that OPCs are able to trigger a mechanism in these degenerated cells of bowel cancer that is also described as programmed cell death. This mechanism is usually (if one is healthy) always triggered when a cell / an association of cells degenerates. When it comes to cancer this mechanism is impaired and the cells start to proliferate. So with OPCs this degenerated cell line was prompted to decompose in a controlled way in this test.

 

It is only hard to understand that - regarding this sensational effect of OPCs, the apoptosis - only relatively less research is being done. There are already a few studies about the effect of flavanoids when fighting off cancer, but if an OPC is capable of killing off cancer cells, would there not be much more research in this area?

 

I always recommend to guard oneself with OPCs if the risk of bowel cancers is high, by taking daily 1 - 2 mg OPCs / kg bodyweight. I personally am not an advocate of high dosed nutrient administrations, but when it comes to such a massive disease like bowel cancer, the question arises if one can argue in favor of a high dose of this natural product under the supervision of a doctor. I think yes, but I also want to note that during chemo / radiotherapy one should maybe not take OPCs, since OPCs are extremely antioxidant and some cancer treatment forms use exactly this oxidation in order to fight off the cancer. SO IF BOWEL CANCER IS ALREADY PRESENT, CONSOLIDATE YOUR DOCTOR BY ALL MEANS BEFORE TAKING OBCS.

 

Sources:

 

Y.J. Kim / H. J. Park / S.H. Yoon / M. J. Kim / K.H. Leem / J.H. Chung / H.K. Kim: Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4. in: World J. Gastroenterol. 11(30) (2005), 4674-4678

 

https://de.m.wikipedia.org/wiki/Apoptose

 

Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000; 52: 673-751

 

Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Hinghorn AD, Mehta RG, Moon RC, Pezzuto JM. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997; 275: 218-220

 

Ye X, Krohn RL, Liu W, Joshi SS, Kuszynski CA, McGinn TR, Bagchi M, Preuss HG, Stohs SJ, Bagchi D. The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol Cell Biochem 1999; 196: 99-108

Dementia

Effect of OPCs - Dementia

 

The Latin term dementia describes a psychiatric syndrome which mostly arise at an older age and which affects the mind and cogitation of a person. Alzheimer’s disease is also a part of the main term dementia. When it comes to dementia, one distinguishes between degenerative and not degenerative symptoms, whereby degenerative means that the affected organ underlies an degradation process. So not degenerative would be a dementia, where the brain power is quickly restricted due to toxic substances and that the brain can regenerate itself again.

 

In both versions of dementia it makes sense to take OPCs in combination with vitamin C, since these vital substances overcome the blood-cerebral barrier and have an extremely powerful effect as radical scavengers in the brain with highly antioxidant features. Besides his excellent features as antioxidant while fighting off dementia, OPCs are also a strong anti-inflammatory. On top of that, OPCs also help to get rid of metabolic waste in the brain and to make the transport of nutrients into the brain cells easier.

 

When it comes to dementia that is bred in the brain due to vessel problems, OPCs help to repair the vessels and to seal them. This way the circulation of the brain is being additionally optimized with OPCs.

 

OPCs help with dementia

 

OPCs improve the circulation in the brain in case of dementia.

OPCs regenerate the vessels in the brain in case of dementia.

OPCs help as antioxidants in case of dementia.

OPCs protect the brain from free radicals.

OPCs increase the healing of inflammations.

OPCs optimize the cell supply.

OPCs strengthen the antioxidant effect of vitamin C by 1000%.

 

In order to achieve an optimal preventive effect and to protect the brain from dementia, you should take 1 - 2 mg OPCs / kg bodyweight daily - ideally in combination with natural vitamin C so that the antioxidant features of these vital substances can be maximized in the brain and a long-term protection can be established.

With acute / chronic dementia you can take 1 - 5 mg OPCs / kg bodyweight after consultation with your doctor.

 

 

Sources:

 

Pasinetti, G. M., et al., „Grape-Derived Polyphenolics Prevent A-beta Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer’s Disease“, Journal of Neuroscience, June 2008, Volume 28, Pages 6388-6392.

 

Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, Stohs SJ. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 1997; 95: 179-189

 

Fitzpatrick et al. Endothelium-dependent vascular effects of Pycnogenol®. J Cardiovas Pharmacol 32: 509-515, 1998 and also: Belcaro G et al. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol®. Angiology 56: 699-705, 2005

 

Dr. Walter Brohmüller Scholte, BookRix-Verlag, „OPC das Super-Antioxidans.“: Plant extract with proanthoeyainidins content as therapeutic agent having radical scavenging effect and use thereof, U.S. Patent Nr. 4.698.360 (Okt. 1987)

Diabetes

Effect of OPCs - Diabetes

 

In the vernacular diabetes is also called sugar disease and is one of the most wide spread diseases of civilization. If a person has diabetes the sugar metabolism is out of balance and in the urine of a person with diabetes one can see that more sugar is being excreted.

 

If something in the human organism is not right with the sugar balance - which is the case with diabetes - one can often assume that something is also going wrong with the insulin secretion.  Because insulin is the main regulating hormone for the sugar metabolism and responsible for bringing sugar into the cells in order to produce energy. Figuratively speaking it's like this: If insulin is in contact with the cells, they open up for sugar storage.

 

Now there are many different reasons why this mechanism doesn't really work well anymore - the consequence can be diabetes, where either the cells developed insulin resistance or the pancreas doesn't produce a sufficient amount of insulin anymore.

 

Researchers from many different universities now discovered in the last few years that polyphenols (that OPCs are a part of) definitely have an effect on the blood sugar balance. Unprofessionally speaking, Polyphenol / OPCs help to hold the blood sugar on a consistent level according to that study.

 

Scientists of the University of Leeds in England marked in their release in 2012, that the insulin sensitivity was improved in their review of the already existing research results about the influence of polyphenols on the blood sugar level. The fasting blood sugar level was optimized by polyphenols according to the research results, as well as the release of insulin itself.

 

This is in great part in accord with the most interesting study about the influence of OPCs / Polyphenols on diabetes resp. on the blood sugar level.  This study from the year 2013, which has been done on the Spanish University Rovira I Virgili in Tarragona proves that the procyanidins from grape seed extracts are inhibitors of certain enzymes.

 

Proanthocyanidins from grape seeds therefor inhibit dipeptidyl peptidase 4 (DPP4). With the inhibition of DPP4 the depletion of GLP-1 (Glucagon-like Peptid 1) is being prevented in the organism.

This has a very positive effect on the insulin balance, because this way the insulin release is only being increased when food is actually taken in (and only then when higher blood levels on GLP-1 are available). Subsequently hypoglycemia is being prevented.

 

OPCs modulate the insulin secretion while eating food:

 

OPCs inhibit DPP4

OPCs block the depletion of GLP-1

 

--> Hypoglycemia is being prevented

In order to prevent diabetes I always recommend 1 - 2 mg OPCs / kg bodyweight per day together with vitamin C, because both of these function as a synergetic nutrient matrix in strengthen themselves mutually in their effects.

If one is already suffering from diabetes the intake of OPCs should be discussed with the doctor. I recommend a slow intake starting at 1 mg OPCs per kg bodyweight per day (so a person with 80 kg takes 80mg OPCs). This can be increased to the amount that is necessary in order to achieve a stable blood sugar level.

 

Sources:

 

Procyanidins and their healthy protectife effects against Type-2-Diabetes, 2015, onzalez-Abuin, Noemi / Pinent, Montserrat / Casanova-Marti, Angela / Arola, Lluis / Blay, Mayte / Ardevol, Anna. · · Departament de Bioquimica i Biotecnologia, C. Marcel.li Domingo s/n, 43007 Tarragona, Spain. montserrat.pinent@urv.cat. ·Curr Med Chem · Pubmed #25245512.

 

 

Grape Seed-Derived Procyanidins Decrease Dipeptidyl-peptidase 4 Activity and Expression, 2012. González-Abuín, Noemi / Martínez-Micaelo, Neus / Blay, Mayte / Pujadas, Gerard / Garcia-Vallvé, Santiago / Pinent, Montserrat / Ardévol, Anna. ·Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Tarragona, Spain. · ·J Agric Food Chem · Pubmed #22891874.

 

Thompson, L. U., Relationship between polyphenol intake and blood glucose response of normal and diabetic individuals, Am J Clin Nutr. 1984 May;39(5), S. 745 – 51.

 

Hanhineva, K., Impact of dietary polyphenols on carbohydrate metabolism, Int J Mol Sci. 2010 Mar 31;11(4), S. 1365 – 402.

 

Williamson. G., Possible effects of dietary polyphenols on sugar absorption and digestion, Mol Nutr Food Res. 2013 Jan;57(1), S. 48 – 57.

Circulatory Disorders

Circulatory Disorders

Effect of OPCs - Circulatory Disorders

 

Circulatory disorders are one of the main causes for severe second diseases. There are 3 factors that normally lead to circulatory disorders:

 

·        Weak delivery rate of the heart

·        Inconvenient blood features (e.g. high viscosity)

·        Disturbed vascular function (vascular constriction, vascular permeability, vessel elasticity)

 

Circulatory disorders are especially common in the industrial nations which concerns the health situation of the well-fed nation. So it's no wonder that the cardiovascular diseases are the number one cause of death as a consequence of circulatory disorders especially in western healthcare and of course bothers the affected people.

 

But not only the cardiovascular system is affected by circulatory disorders, but also every organ that is reliant on an optimal blood supply with oxygen, nutrients, co-nutrients and important "helper cells". That's why it's only logical that circulatory disorders lead also to many problems that can often only be treated symptomatically.

 

Circulatory disorders have a negative effect on:

 

·        Skin, hair, nails

·        Cardiovascular System

·        Digestive system

·        Nervous system and brain power

·        Bones and joints

·        Breath

...

 

So if circulatory disorders can be prevented or corrected in the body a lot of symptoms can subside subsequently. If one has excluded genetic dispositions for circulatory disorders, especially the modern lifestyle contributes its part to this widespread disease.

 

·        A lack of movement can lead to.

·        Bad nutrition can lead to.

·        Unhealthy habits can lead to.

 

It's good to know that OPCs - the oligomer proanthocyanidins that are extracted from grape seeds and pine bark - can be used with great success for circulatory disorders. The reason for that on the one hand is that OPCs do their work when it comes to vessel regeneration and on the other hand influence the viscosity of the blood in a positive way. On top of that, OPCs (as the strongest antioxidant) work as the optimal free radical scavenger (harmful oxygen compounds). These often play a huge role when it comes to circulatory disorders and massively harm healthy tissue.

 

A huge part of the human vessels consist of collagenous tissue / elastin that can also be attacked by free radicals and other "pests". Just think of the borrelia that are passed on by ticks and that can work their way through the fine walls of the capillaries of our vessels and cause inflammations in the  screens of the vessels.

 

In the decades-long research of professor Masquelier, who invented the OPCs manufacturing process, a lot of studies showed that very special parts of the OPCs repair again the fragments in the collagen and this way the tissue is being renewed.

 

·        When it comes to circulatory disorders, OPCs restore the stability and elasticity of the affected collagenous tissue.

 

This means that a causal overhaul can happen with the help of OPCs when it comes to circulatory disorders that were created due to the fragility or loss of stability of the vessels. So it's no wonder that France, the homeland of the OPC inventor, accepted this effective natural substance as medicine for circulatory disorders and that it's already being used in hospitals for many years.

 

When it comes to circulatory disorders, OPCs especially help with:

 

·        the repair of attacked collagen, that the vessels are made of.

·        fighting off the vessel enemies (free radicals) as an antioxidant.

·        the decrease of the viscosity and improve the blood flow.

·        the prevention of thrombosis.

·        the active removal of deposits in the vessels.

·        the recovery of the stability and at the same time the elasticity of vessels.

·        counteracting vessel inflammations.

 

So whoever wants to "renew" their vessel system and wants to get rid of already existing circulatory disorders, should take OPCs by all means. In this context it's especially important that OPCs work together with vitamin C, which is essential for the collagenous buildup in the body. It is proven that OPCs increase the effect of vitamin C by 1000%, that's 10-fold. This is a sensation and a reason alone to use OPCs for circulatory disorders, since vitamin C has a great effect as an antioxidant.

 

Take 1 - 2 mg of OPCs per kilogram bodyweight daily in order to prevent circulatory disorders (together with at least ca. 80 mg vitamin C in order to fully make use of the nutrient synergy effect of these both nutrients).

If you already suffer from circulatory disorders, I suggest you to consult your doctor before you start taking a higher dose of 2 - 4 mg OPCs per kilogram bodyweight / day. Since OPCs also improve the viscosity of the blood, a doctor should monitor the intake in case that one has already taken blood thinning medicine. Perhaps the medicine could be reduced, but only a doctor can determine that.

 

Sources:

Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res. 2002;16 Suppl 1:S1-5.

 

Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine. 2000;7(5):383-388

 

Protective effect of wine in laboratory animals fed a cholesterol-enriched diet. FayMorgan, A., Brinner, L., Plaa, C.B. und Stone, M.M., Amer. J. Physiol. 189:290 (1957)

 

Procyanidins from pine bark: Relationships between structure, composition and antiradical activity, 2007 Food Chemistry; María Jerez, Sonia Touriño, Jorge Sineiro, Josep Lluís Torres, María José Núñez

 

Eine neue Therapie für Venenkrankheiten, Feine-Haake, G., Zeitschrift für Allgemeinmedizin, 51:7, 839

 

Arcangeli P. Pycnogenol in chronic venous insufficiency. Fitoterapia. 2000;71(3):236-244

 

Jerez et al., „A comparison between bark extracts from Pinus pinaster and Pinus radiata: Antioxidant activity and procyanidin composition“; 2005; DOI:10.1016/ j.foodchem.2005.09.064

 

Cholesterol and foam cell control with OPC: The atherosclerotic antidote White, David, Internationale Konferenz der OPC-Forschung, Bordeaux, Frankreich,1990

 

Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (pinus maritima) bark, pycnogenol 1999 Free Radical Biology and Medicine, L Packer, G Rimbach, F Virgili

Dysbiosis

Effect of OPCs - Dysbiosis

 

Dysbiosis (also known as dysbacteriosis) is a bad bacterial settlement which can go from the mouth, throat over the stomach down to the intestine. The gut flora is out of balance if you have dysbiosis. But a healthy gut flora is important for the functions of the bowel mucosa and that's why dysbiosis needs to be healed as quickly as possible.

 

More and more doctors decide to examine the gut flora, when the cause of a disease is unclear, and to treat is in case of dysbiosis.

 

The possible consequences of a dysbiosis are:

 

·        Weakening of the immune system.

·        Leaky Gut Syndrome.

·        Diarrhea.

·        Congestion.

·        Flatulence / Meteorism.

·        Cramps.

·        Allergic reactions.

·        Psychological problems (from depression to insomnia).

·        Metabolic diseases.

·        Metabolic syndrome.

·        Intestinal inflammation.

and much more.

 

When the dysbiosis is eliminated and the gut flora is balanced, then a stable base for keeping up general health is being given. Many subsequent diseases that are often only symptomatically treated and possibly went into chronic status, can be eased by healing dysbiosis.

 

Since the dysbiosis often also burdens inflammatory processes in the bowel mucosa, OPCs can also be used for the treatment in order to increase the healing processes and to reduce the inflammation occurrences. If a Leaky-Gut-Syndrome is already formed as a consequence of the dysbiosis, where the tightness of the gut is not guaranteed anymore, OPCs can even be used as one of the most effective measures against gut-leakage.

 

The OPCs - Effects with dysbiosis:

 

OPCs work antiphlogistic with dysbiosis.

OPCs work against the Leaky-Gut-Syndrome of the dysbiosis.

OPCs help to get rid of metabolic waste products of the dysbiosis.

OPCs lower the number of free radicals during a dysbiosis.

OPCs strengthen the immune system, which is weakened by the dysbiosis.

OPC helps with the fast regeneration of the affected mucosae.

 

 

In order to optimally profit from the effect of OPCs when it comes to dysbiosis, the OPCs should definitely be taken on an empty stomach. Until the dysbiosis goes away you can take 2 - 4 mg OPCs / kg bodyweight per day and then reduce to a maintenance dose of 1 - 2 mg OPCs / kg bodyweight / day in order to get rid of the consequences of the dysbiosis much faster.

 

Sources:

Chronic administration of dietary grape seed extract increases colonic expression of gut tight junction protein occludin and reduces fecal calprotectin: a secondary analysis of healthy Wistar Furth rats. By Goodrich, Katheryn M.; Fundaro, Gabrielle; Griffin, Laura E.; Grant, Ar'Quette; Hulver, Matthew W.; Ponder, Monica A.; Neilson, Andrew P.

From Nutrition Research (New York, NY, United States) (2012), 32(10), 787-794. Language: English, Database: CAPLUS, DOI:10.1016/j.nutres.2012.09.004

 

Sen CK, et al. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci 2002; 957: 239–49

 

Khanna S, et al. Dermal wound healing properties of redox-active grape seed proantho- cyanidins. Free Radic Biol Med 2002; 33(8): 1089–96

 

Holzhauer P et al. Prophylaxe der Chemotherapie-assoziierten oralen Mukositis

Deutsche Zeitschrift für Onkologie 2015; 47: 36–40

Eczema

Effect of OPCs - Eczema

 

Eczema are one of the most occurring skin diseases and is also known as dermatitis. There are many different classifications of eczema that all have in common to show themselves as a noninfectious inflammation reaction.

On the sequence of skin reactions alone you can already narrow down if it's an eczema or not, since eczema always show a typical sequence.

 

Course of the skin reactions with eczema:

Erythema -> Blistering -> Weeping -> Crust Formation -> Desquamation

 

Eczema can have many causes / triggers, the consequence, however, is always an inflammatory reaction of the skin. Besides avoiding contact with the triggers for eczema an ointment is usually prescribed which helps healing the eczema.

 

On top of that one can reduce the inflammatory reactions of the eczema by using OPCs, because OPCs have a very positive effect on the reduction of the inflammation mediators. The histamine release can be reduced with OPCs and the healing process of the skin can also be accelerated / optimized with the so-called oligomer proanthocyanidins.

 

OPCs can be helpful with eczema

 

·        lowers the histamine release / inflammatory reaction.

·        improves the circulation of the skin.

·        helps to heal the skin quicker.

·        improves the nutrient supply of the attacked skin.

 

If you tend to have eczema, you can take 1 - 2 mg OPCs / kg bodyweight for prevention. If you currently have eczema you can ask your doctor for a higher dosage in order to increase the healing process of the inflammation (since OPCs do not have any side effects, the doses over 5 mg OPC / kg bodyweight are unproblematic, unless you have a very sensitive stomach. In this case you can take OPCs after eating.)

 

Since OPCs work synergetic with vitamin C, you should make use of this synergy effect for a quicker healing of your skin. When it comes to eczema, take at least 80 mg of vitamin C a day in addition to OPCs since vitamin C is essential for collagen formation.

 

Sources:

Hughes-Formelia B., Wunderlich O., et al., „Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins.“ ;Skin Pharmacol Physiol. 2007;20(1):43-9. Epub 2006 Oct 11

 

Fitzpatrick et al. Endothelium-dependent vascular effects of Pycnogenol®. J Cardiovas Pharmacol 32: 509-515, 1998 and also: Belcaro G et al. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol®. Angiology 56: 699-705, 2005

 

Sen CK, et al. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci 2002; 957: 239–49

Elasticity of the skin

Effects of OPCs - Elasticity of the skin

 

The elasticity of the skin is mainly dependent on healthy collagenous compounds of the skin tissue and that they don't have any damages. In terms of skin elasticity, elastin also plays an important role, which belongs to the main term collagen.

Collagenous fiber can in some circumstances be damaged. This can then lead to less water storage in the collagen. You can imagine the structure of the skin collagen like a ladder and if the rungs of this ladder are broken, the skin is lacking elasticity as well as stability. The skin then looks often wrinkly, rough, pale and just not "fresh" and healthy anymore.

 

Possible causes for a loss of elasticity in the skin:

 

·        Smoking can negatively influence the.

·        Too less sleep can worsen the.

·        Bad nutrition can lead to a reduction of the.

·        Environmental toxins can influence the.

·        The can be heavily attacked with too much sun.

 

Of course the genetics can contribute that the elasticity of the skin is outside the norm according to the make-up, but that is not the rule, but an exception.

 

OPCs, the oligomer proanthocyanidins, are able to repair damaged collagenous fiber again and help with the buildup of new collagenous tissues. The OPCs, that have been invented by French scientist professor Jacques Masquelier help to restore the elasticity of the skin. OPCs have many positive effects on the elasticity of the skin and should ideally be used as a preventive measure in middle age.

 

OPCs improve the elasticity of the skin:

 

OPCs rebuild collagen and elastin.

OPCs reduce the free radicals of burdened skin.

OPCs help with the repair of skin damages.

OPCs increases the effect of vitamin C by 1000%.

OPCs improve the circulation of the skin.

OPCs optimize the skin metabolism.

 

Since vitamin C is especially important for the buildup of collagen, it should be taken in a synergetic nutrient complex with OPCs in order to restore the elasticity of the skin.

Take 1 - 2 mg of preventive OPCs per kg bodyweight a day, together with at least 80 mg vitamin C. When the elasticity of the skin already suffered, you can take 2 - 4 mg OPCs per kg bodyweight in order to improve the skin.

 

Sources:

 

Stabilisation du collagene par des oligomeres procyanidoliques; Acta Therapeutica 7:101-5 (1981).

Hughes-Formelia B., Wunderlich O., et al., „Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins.“;Skin Pharmacol Physiol. 2007;20(1):43-9. Epub 2006 Oct 11

 

Khanna S, et al. Dermal wound healing properties of redox-active grape seed proantho- cyanidins. Free Radic Biol Med 2002; 33(8): 1089–96

Inflammation

Effects of OPCs - Inflammation

 

An inflammation is an immune reaction of the body to "intruders" like contaminants or germs. With the inflammation the intruder should be driven out of the cells. Usually a very desirable reaction if this happens in an ordered resp. normal way.

But it can also happen that the body already reacts with an inflammation even if the cause is almost not harmful at all - the immune system overreacts and in the worst case this is called an allergy.

 

The easier it is for the body to remove intrudes resp. to eliminate them and to remove the resulting metabolic waste, the quicker an inflammation can subside and the stressed area can heal.

If then the amount of inflammatory mediators (e.g. histamine) is being held on a normal level, the symptoms of an inflammation are much more bearable.

 

Here the usage of OPCs begins. The oligomer proanthocyanidins (abbreviation: OPCs) are able to massively help the burdened tissue structures in their healing process, because OPCs own strong tissue regenerative features. On top of that, OPCs help to transport important nutrients to the cells and speed up the removal of waste products form the cells. OPCs also operate in a vessel caulking way.

The partly massive emission of histamine and other inflammatory mediators during an inflammation should also be reduced with OPCs which makes the symptoms much more bearable.

 

OPCs vs. Inflammations - a balance:

 

OPCs have an decongestant effect.

OPCs reduce the inflammatory mediators resp. their release.

OPCs help regenerate attacked tissue.

OPCs optimize the transport of nutrients into the cells.

OPCs optimize the transport of toxins from the cells.

 

If one has an acute or chronic inflammation you can consult your doctor and maybe take 2 - 5 mg of OPCs per kg bodyweight per day until the inflammation gets better.

As a maintenance dose resp. in order to prevent an inflammation, you can take 1 - 2 mg of OPCs per kg bodyweight per day.

The combination of OPCs with vitamin C (at least 80 mg per day) is ideal, since OPCs increase the antioxidant features of vitamin C 10-fold.

 

Sources:

 

Seiler, Benjamin – „OPC-Die Kernkraft, die dem Leben dient“; Zeitenschrift Ausgabe 62

 

Dr. D. White, Internationales OPC-Symposium, 1990; vitalesleben.com

 

J Med Food. 2003 Winter;6(4):291-9. Polyphenolics in grape seeds-biochemistry and functionality. Shi J, Yu J, Pohorly JE, Kakuda Y. Food Research Center, Agriculture and Agri-Food Canada, Guelph, Canada. shij@agr.gc.ca

Dr. Walter Brohmüller Scholte, OPC-Das Super-Antioxidans, BookRix GmbH, ISBN 978-3-7368-9493-8

Fatigue syndrome

Effect of OPCs - Fatigue Syndrome

 

In the meanwhile the fatigue syndrome (which should not be confused with burnout) is known as a symptom group and many people suffer from it. The fatigue symptom can be developed as a consequence of diseases like cancer, fibromyalgia, morbus XY, etc., but the fatigue symptom also found its way into the doctor's offices as an independent (unclear) disease. In case that it appears independently, unrelated to a "main disease", it is called chronic fatigue symptom.

 

The symptoms of the fatigue symptom can be widespread and start with continuing tiredness over concentration disorders and not relaxing sleep up to neurological disorders.

 

Since OPCs have a broad action spectrum and optimally influence inflammation occurrences, as well as repair procedures in the body, they are also perfectly suitable for the fatigue symptom in order to fight off the single symptoms.  Unfortunately there are no concrete studies to the usage of OPCs with fatigue syndrome, because this symptom is not very clear regarding the individual symptoms of this disease that the people suffer from.

 

OPCs help with inflammations in the body.

OPCs activate the body's own self-healing power

OPCs reduce the pressure with free radicals.

OPCs are the strongest antioxidant worldwide.

OPCs repair collagenous tissue in the body.

OPCs also work in the brain, since they overcome the blood-cerebral barrier

OPCs stabilize the cardiovascular system.

OPCs promote the circulation.

 

With the help of OPCs of grape seed extract and pine bark extract, you definitely help the body to fight off the symptoms of the fatigue symptom in the body much better. This can easily help with the healing process of the fatigue symptom, depending on the cause, whereby, however, one should not lose patience if the recovery takes some time. The success is also dependent on how consistent possible causes for the fatigue syndrome are eliminated.

 

For a long-term usage and also as a preventative measure of the fatigue symptom you should take 1 mg of OPCs per kg bodyweight a day. If you have acute symptoms that need to be fought off purposefully, you can take 2 - 5 mg of OPCs / kg bodyweight just like that. Since no side effects could be proved when taking OPCs and there are no hints to a possible overdose (if you have a sensitive stomach, you should, however, maybe take the OPCs after a meal) after decades of research, you can also take higher doses for fatigue syndrome.

Depending on the seriousness of the disease, you should also talk to your doctor.

 

Sources:

Condensed tannins scavenge active oxygen radicals, Uchida, Shinji, Edamastu, Rei, et.al. Med. Sci., Res., 15:831-2 (1980)

 

„Plant extract with a proanthocyanadins content as therapeutic agent having radical scavenging effect and use thereof, United States Patent Nr. 4.698.360 (6. Oktober 1987)“

 

Dr. Walter Brohmüller Scholte, Gabriele Simon & Helmut Achterath. „OPC das Super-Antioxidans.“

 

Chronic administration of dietary grape seed extract increases colonic expression of gut tight junction protein occludin and reduces fecal calprotectin: a secondary analysis of healthy Wistar Furth rats; By Goodrich, Katheryn M.; Fundaro, Gabrielle; Griffin, Laura E.; Grant, Ar'Quette; Hulver, Matthew W.; Ponder, Monica A.; Neilson, Andrew P.

 

Hosseini et al., „A randomized, double-blind, placebo controlled, prospective 16 weeks crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patients; Nutr Res 21(9):67-76, 2001

 

Cholesterol and foam cell control with OPC: The atherosclerotic antidote White, David, Internationale Konferenz der OPCforschung, Bordeaux, Frankreich (4.-6. Oktober 1990)

 

Belcaro G, Cesarone MR, Rohdewald P, et al. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost. 2004;10(4):373-377

Free Radicals

Effect of OPCs - Free Radicals

 

Free radicals are very aggressive oxygen compounds that are highly reactive and can do a lot of damage to the body. They start so-called oxidation processes where body cells are massively damaged. Free radicals are created through the reaction of molecular oxygen (O2) in the metabolic process of the body cells.

 

So "usually" a normal process, which is basically given through the breath of a human being. The body is also able to work against these free radicals and forms its own "radical scavengers".

According to the theory of the biogerontologist D. Harman, the free radicals are responsible for the aging process of the body, since more free radicals are influencing the body over time and the organism cannot manage the mass of free radicals with the production of antioxidants anymore.

 

Luckily, besides the body's own antioxidants (e.g. catalase and urate) there are also substances that are taken in with the foods we eat and that are able in the metabolism to bind these free radicals. Among others, vitamin C, vitamin E and other vital substances are very well known and neutralize active free radicals.

 

The discovery of the OPCs (oligomer proanthocyanidins) by Prof. Dr. Jacques Masquelier sounded the bell for a new computation of time when it comes to fighting off free radicals. In his decades-long research with the extracts of French grape seeds and pine bark, he could prove that these OPCs are the strongest radical scavengers worldwide.

 

OPCs -> 50 x stronger than vitamin E

OPC -> ca. 18 times stronger than vitamin c

 

On top of that he discovered the unbelievable nutrient synergy component of the OPCs and showed in his scientific paper that OPCs increase the antioxidant effect of vitamin C and vitamin E by approximately 1000%. If vitamin C and vitamin E are taken together with OPCs they unfold a 10-fold effect regarding the elimination of free radicals. So it's no wonder that the intake of OPCs already show outstanding regenerative results after only a short amount of time.

 

OPCs neutralize free radicals and among others bring about:

 

·        Optimal regeneration of body cells. Faster healing.

·        Improvement of the circulation.

·        Quicker repair of collagenous tissue.

·        The transport of contaminants from the cells is being eased.

·        The transport of nutrients in the cells is being optimized.

·        The vulnerability for infectious diseases decreases..

·        The brain power increases.

·        The cardio-vascular system and all organs are being protected.

·        The quality of the skin improves in a short amount of time.

·        Visible and non-visible aging processes are slowed down.

 

These are just a few aspects when it comes to the consequences of the intake of OPCs in order to neutralize free radicals. The positive consequences of OPCs against free radicals are even more comprehensive and I always suggest to supplement with OPCs when it's about fighting off the early aging process.

 

Take 1 - 2 mg of OPCs / kg bodyweight  in order to create a protection from free radicals. The combination of OPCs with vitamin C is ideal, since the collagen formation is extremely increased this way, the vessels / tissue gets more elastic and the free radicals are fought off more effectively.

 

Sources:

 

D. Harman: Aging: a theory based on free radical and radiation chemistry. In: Journal of Gerontology 11, 1956, S. 298–300, PMID 13332224

 

Hughes-Formelia B., Wunderlich O., et al., „Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins.“;Skin Pharmacol Physiol. 2007;20(1):43-9. Epub 2006 Oct 11

 

Sen CK, et al. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci 2002; 957: 239–49

 

D. Harman: The free radical theory of aging. In: Antioxid Redox Signal 5, 2003, S. 557-561, PMID 14580310.

 

Stabilisation du collagene par des oligomeres procyanidoliques; Acta Therapeutica 7:101-5 (1981).

 

Khanna S, et al. Dermal wound healing properties of redox-active grape seed proantho- cyanidins. Free Radic Biol Med 2002; 33(8): 1089–96

 

D. Harman: Free radical theory of aging. In: Mutat Res 275, 1992, S. 257–266, PMID 1383768.

 

Yasumuro M et al. Inhibition of melanogenesis by pine (Pinus pinaster) bark extract containing procyanidins. Manuscript in preparation 2006

 

H. C. Schröder: Superoxidradikale, Genexpression und Alterung: Reparable Schäden auf der Ebene der DNA und irreparable Schäden auf der Ebene der mRNA Reifung. In: Erfolgreiches Altern, M. M. Baltes, M. Kohli und K. Sames (Hrsg.), Verlag Huber, 1989, ISBN 3-456-81841-6 S. 259–269.

 

G. G. Duthie u. a.: Oxidants, antioxidants and cardiovascular disease. In: Nut Res Rev 2, 1989, S. 51–62, PMID 19094346.

 

T. Schmidt u. a.: Physiologische Potentiale der Langlebigkeit und Gesundheit im evolutionsbiologischen und kulturellen Kontext - Grundvoraussetzungen für ein produktives Leben. In: Produktives Leben im Alter M. Baltes und L. Montada (Hrsg.), Campus-Verlag, 1996, ISBN 3-593-35456-X S. 69–130.

 

B. N. Ames u. a.: Oxidants, antioxidants, and the degenerative diseases of aging. In: PNAS 90, 1993, S. 7915–7922, PMID 8367443, PMC 47258 (freier Volltext).

Gastritis

Effect of OPCs - Gastritis

 

Gastritis is an inflammation of the stomach mucosa which can be genetically, bacterially or biochemically dependent. In the end gastritis forms inflammatory sites in the stomach until the pyloric orifice which can also lead to gastric ulcers.

 

Since OPCs help with all inflammations in the body, heal them faster and also have features that have a positive effect on the repair of the body mucosae, OPCs can especially be helpful with gastritis. The organism which is weakened by the gastritis can quickly be regenerated with the help of OPCs. The metabolic products that arise with gastritis, are more easily wicked away and at the same time the mucosal cells of the stomach are better supplied with nutrients through the OPCs.

 

OPCs can help stabilize the attacked immune system of chronic, as well as acute gastritis. If one decides to take high-quality OPCs capsules as a food supplement for gastritis one should keep in mind that the stomach can react a little bit sensitive when the OPC capsules are taken on an empty stomach. If one opens the OPC capsules, puts the content into a warm glass of water and drinks it quickly, the entire stomach can be covered with it without having a high OPC concentration in only one part of the stomach.

 

OPCs help with gastritis

 

OPCs regenerates the mucosae.

OPCs stabilize the immune system.

OPCs help with the healing of inflammations.

OPCs reduce inflammation appearances.

OPCs helps with the healing of injured skin / mucosae.

OPCs optimizes the transport of pollutants from the cells.

OPCs improve the nutrient transport into the cells.

 

Take 1 - 2 mg of OPCs per kilogram of bodyweight in a glass of water a day if you have a sensitive stomach. Then you can progressively increase your dose up to 5 mg of OPCs / kg bodyweight (a woman with 60kg in this case takes 300 mg OPCs a day). Depending on the form of the gastritis, you should talk with your doctor before taking OPCs. Basically one can perfectly prevent gastritis with the first named minimal dose.

 

Sources:

 

Holzhauer P et al. Prophylaxe der Chemotherapie-assoziierten oralen Mukositis; Deutsche Zeitschrift für Onkologie 2015; 47: 36–40

 

Khanna S, et al. Dermal wound healing properties of redox-active grape seed proantho- cyanidins. Free Radic Biol Med 2002; 33(8): 1089–96

 

Procyanidins from pine bark: Relationships between structure, composition and antiradical activity, 2007 Food Chemistry; María Jerez, Sonia Touriño, Jorge Sineiro, Josep Lluís Torres, María José Núñez

Memory

Effect of OPCs - Memory
 

Whoever wants to whip their memory into shape can do this very well with OPCs. Since OPCs (Oligomer Procyanidins) can easily overcome the blood-cerebral barrier, these natural healing substances also enfold their effect fully in the brain. There, the OPCs help for a better memory by optimizing the circulation of the brain.

 

But not only the improved circulation of the brain plays a part in contributing to a better memory, because OPCs have a much broader action spectrum. OPCs - from grape seeds and pine bark extract plant substances - are known for dismantling deposits and to quicker heal inflammatory processes. On top of that they repair attacked tissue by overhauling the fragments in the collagenous fiber. The brain profits form that and of course especially the power of the memory.

 

The most probably biggest factor of the OPC effect, when it comes to the memory, is the fact, that OPCs are the strongest weapon against free radicals. Its effect as an antioxidant is 18 times higher than of vitamin C and, believe it or not, 50 times higher than vitamin E. On top of that, OPCs increase the effect of these two vitamins 10-fold (by 1000%!) according to the research of the OPC inventor Prof. Dr. Jacques Masquelier.

 

This way, OPCs (ideally in combination with vitamin C) builds a sensational protection for brain and memory. Free radicals do not have any chances to have an negative impact on the memory and the mental power increases.

 

OPCs improve the memory:

 

·        The circulation is improved.

·        The blood vessels are being repaired and kept elastic.

·        The cells in the brain are protected from free radicals.

·        Repair damaged collagenous tissue in the brain.

·        This way, possible inflammations in the brain can heal faster.

·        The metabolism of the brain is being optimized.

 

If you want to promote your memory and if you want to prevent loss of performance in age, you can make a contribution by taking 1 - 2 mg OPCs / kg bodyweight per day. You can even take much higher doses if there are acute problems with the memory and increase it to 5 mg OPCs / kg bodyweight. If you have massive medical conditions, talk about the intake of OPCs with your doctor before starting.

 

Sources:

 

Das OPC-Arbeitsbuch, Anne Simons, „2013 Maya Media Verlag Dr. Andreas Gößling, Cobur“

 

Sen CK, et al. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci 2002; 957: 239–49

 

Dr. Walter Brohmüller Scholte, Gabriele Simon & Helmut Achterath. „OPC das Super-Antioxidans. Verlag:BookRix GmbH & Co. KG; 2015

 

Plant extract with a proanthocyanadins content as therapeutic agent having radical scavenging effect and use thereof, United States Patent Nr. 4.698.360 (6. Oktober 1987)

Vessels

Effect of OPC - Vessels

 

The vessels of the human body are exposed to the influences of modern nutrition, environmental toxins and a lack of movement to a special degree. The consequences of that are arteriosclerosis, porous / brittle vessels that can end in severe symptoms like heart attack, stroke and thrombosis.

 

With the usage of OPCs, the oligomer proanthocyanidins, that are available in the form of French grape seed extract and pine bark extract, the vessels can be optimally furnished. Since the 50s of the last century, the OPCs are already researched and especially in France they are also used with great success as a medication in order to treat diseased vessels.

 

Unlike other medication for treating vessels, the OPCs do not have any side effects and additionally have a broad natural action spectrum. This way, the OPCs interfere from different sides and in a healing way with the metabolism of the body resp. the vessels.

 

Many studies proved the effect of OPCs when it comes to the health of the vessels in the human body. Especially for cardiovascular and eye health, healthy, functioning vessels are important. Many eye diseases for example are attributable to vessels in the eye that became diseased and the consequent damages are then shown symptomatically in the well-known eye diseases.

 

With OPCs, the symptoms and, even more importantly, the causes of many diseases can be fought off by healing the vessels.

 

OPCs help with the healing of the vessels in the human body:

 

·        regenerate the collagenous structures of the vessels

·        eliminate free radicals that attack the vessels.

·        dismantle arteriosclerosis and prevents it.

·        are the strongest antioxidant and thus is an effective vessel protector.

·        have a "sealing" effect on porous vessels.

·        prevent thrombosis, heart attacks and strokes.

·        help to heal the inflammation of the vessels.

·        improve the circulation of the vessels.

·        heal even the smallest capillary vessels.

·        strengthen the effect of vital substances 10-fold.

 

Due to the healing of the vessels in the entire body, the subsequent symptoms and severe diseases that result from vessel diseases are being reduced.

 

In order to prevent diseases in the vessels you can take 1 - 2 mg of OPCs / kg bodyweight a day. Ideally you'll take the OPC capsules on an empty stomach. If you have a sensitive stomach than you should better take the OPCs after eating.

 

 

If you have acute disorders in your vessels or subsequent diseases, you can increase the dose step by step to 5 mg OPCs / kg bodyweight after talking to your doctor. Higher dosage are normally not needed.

 

Sources:

Dr. Stefan Siebrecht, Pycnogenol ( OPC Anmk. des Autors ) schützt die Gefäße der Netzhaut, Vitalstoffe, Ausgabe 4 / 2014, S. 30

 

Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine. 2000;7(5):383-388

 

Dr. Stefan Siebrecht, Pycnogenol ( OPC Anmk. des Autors ) reduziert Blutungen im Auge,, Vitalstoffe, Ausgabe 4 / 2014, S. 31

 

Eine neue Therapie für Venenkrankheiten, Feine-Haake, G., Zeitschrift für Allgemeinmedizin, 51:7, 839

 

Cholesterol and foam cell control with OPC: The atherosclerotic antidote White, David, Internationale Konferenz der OPC-Forschung, Bordeaux, Frankreich,1990

 

Dr. Stefan Siebrecht, Die Blutungen der Kapillaren werden durch Pycnogenol ( OPC Anmk. des Autors ) deutlich verbessert. Vitalstoffe, Ausgabe 4 / 2014, S. 32

Brain

Effect of OPC - Brain
 

The brain is our control center from where the spirit is ruling over the body. So the way how well our body functions are being coordinated resp. selected autonomously, is dependent on how well the brain works. The brain, with its approximately 80 billion neurons, synapses and uncountable nerve pathways is a biological high performance device and it is unbelievable that humans only use 10% of their brain capacity to this day and can still have "such results".

 

The brain needs a special protection from substantial and mechanical influences and this way the body has made the perfect provisions against it. There is for example the blood-cerebral barrier that prevents "not authorized" substances to reach the brain. Also lying in a kind of "waterbed" is something special. It is clear that the metabolism has a very high significance for the viability and the quality of life of a human being.

 

The burden of the brain metabolism through harmful substances, that overcome the blood-cerebral barrier, as well as mechanical influences, especially certain diseases, need a special treatment with nutrients that are able to work against the influences. Such a nutrient is OPCs that is extracted from French grape seeds and pine bark. These plant substances are able to protect the brain from the damage through free radicals and help with several processes that are responsible for healing the brain and keeping it healthy.

 

OPCs protect and regenerate the brain

 

OPCs protect the brain from oxidative stress and free radicals.

OPCs have antiphlogistic features and let inflammations subside quicker.

OPCs overcome the blood-cerebral barrier.

OPCs improve the nutrient transport to the brain.

OPCs help eliminate the pollutants in the brain.

OPCs repair the blood vessels in the brain and keep them elastic.

OPCs help with the regeneration of nerves.

 

If you want to protect your brain from harmful environmental impacts - the so-called oxidative stress - and many diseases, than you can already do something with 1 mg OPCs / kg bodyweight a day as long-term supplementation. If you already have symptoms or even diseases in the brain, you should think about increasing the dose of OPCs in steps up to 5 mg / kg bodyweight and day after talking to your doctor.

 

Sources:

 

Sen CK, et al. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci 2002; 957: 239–49

 

Dr. Walter Brohmüller Scholte, Gabriele Simon & Helmut Achterath. „OPC das Super-Antioxidans.“ „Verlag: BookRix GmbH & Co. KG“ / 2015

Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine. 2000;7(5):383-388

 

Bell, Duncan, internationales Symposium über OPC, Bordeaux, Frankreich (Okt. 1990)

 

Procyanidins from pine bark: Relationships between structure, composition and antiradical activity, 2007 Food Chemistry; María Jerez, Sonia Touriño, Jorge Sineiro, Josep Lluís Torres, María José Núñez

 

Seiler, Benjamin – „OPC-Die Kernkraft, die dem Leben dient“; Zeitenschrift Ausgabe 62

 

Stabilisation du collagene par des oligomeres procyanidoliques, Acta Therapeutica 7:101-5 (1981)

 

Auszug aus: Dr. Walter Brohmüller Scholte, Gabriele Simon & Helmut Achterath. „OPC das Super-Antioxidans.“ iBooks.

This material might be copyrighted.

 

This book in the iBooks store is worth reading: https://itun.es/de/s3kC7.l

Cataract and Glaucoma

Effects of OPCs - Cataract and Glaucoma

 

In the ophthalmology OPCs have a special role, since the oligomer proanthocyanidins can take fully effect there. This is especially important nowadays, where diabetes and other diseases of civilization leave its mark on the health of the eyes and often end in cataract and glaucoma.

 

Degenerative pathologic and physiologic processes initiate the decrease of the eyesight with age, whereby there are mainly 4 reasons for loss of vision in age.

 

·        AMD (age-related macular degeneration)

·        Cataract ()

·        Retinopathy (there especially the diabetic retinopathy)

·        Glaucoma ()

 

The meanwhile most common cause for loss of sight in old age is the AMD, before glaucoma and cataract, whereby the diabetic retinopathy in the industrial nations is more and more common and with a missing intervention it will most probably supersede glaucoma from the second place.

 

Luckily cataract can be treated with a surgical correction and not really a reason anymore to go blind. But the surgery of a cataract is also not a trivial one and a guarantee for being able to see. It is always better to prevent the causes for loss of eyesight resp. to stop their progression and to regenerate the eyes, without ending up immediately under the laser.

 

It's often free radicals / oxidative stress and nutritional factors that attack the eye tissue and lead to damages that partly also contribute to cataract and glaucoma. The body tissue with the highest metabolic rate is the retina. The most oxidative stress is also produced here. On top of that, visible blue light and the UV-rays in the eye create free radicals every single day.

 

Even the macula, that sits in the middle of the retina, is under high pressure, because it also needs to withstand the energized uv-light and blue light. Since the central vision happens in the macula, it is very important that this part of the eyes is especially protected. Our creator protected the macula with lutein which can be found in the form of carotenoid in a lot of vegetables.

 

The following vegetables contain lutein in relevant amounts:

 

·        Kale

·        Spinach

·        Rocket

·        Green Cabbage

·        Cress

150 g green cabbage / day contain, according to a study of the University Jena, enough lutein in order to meet the needs of the eyes.

 

A study (Nakanashi-Ueda et al, J Clin Biochem Nutr. 38: 204-210, 2006) showed, that the antioxidant effect of lutein in combination with OPCs have enormous synergetic features so that the nutrient synergy complex has a 60% higher antioxidant power than the sum of the single ones. This is sensational and shows how OPCs can extremely increase the effect of vital substances in the body with the nutrient synergy.

 

That's why I recommend taking the above mentioned vegetables possibly raw during the intake of OPCs for the prevention or treatment of eye diseases like cataract, in order to profit from the nutrient synergy from OPCs + lutein and to maintain eyesight.

 

With the help of OPCs you can make an important contribution to the health of your eyes and prevent the development of cataract, glaucoma, macular degeneration from old age and retinopathy and maybe even delay, stop the progress and grant the eyes excellent care.

 

OPCs help with diseases like cataract and glaucoma.

 

OPCs help in the eyes as the strongest free radical scavenger.

OPCs protect together with lutein the macula from damage through light.

OPCs seal the fine capillaries and reduce bleedings in the eyes.

OPCs help to heal inflammatory progresses faster.

OPCs improve the circulation of the eyes.

OPCs repair the eye tissue if collagenous structures are affected.

OPCs optimize the nutrient supply of the eyes.

 

In order to prevent cataract and glaucoma, take 1 mg of OPCs / kg bodyweight a day and make sure that your daily meals include the vegetables that were named on top. If you already have a diagnosis resp. symptoms then you can talk to your doctor and you might be able to increase your dose up to 5mg OPCs / kg bodyweight and you should also take vitamin C additionally as well as rich meals or appropriate dietary supplements (at least 80 mg vitamin C / day), since the effect of OPCs increases the effect of vitamin C (the formation of collagen, antioxidant etc.) 10-fold.

 

Sources:

 

Nakanashi-Ueda T et al- Inhbitory effect of Lutein and Pycnogenol ( OPC – anmk. des Autors) on lipid peroxidation in porcine retinal homogenate. J Clin Biochem Nutr 38: 204-210, 2006.

 

Steigerwalt, RD Jr., Belcaro G., Morazzoni P., Bombardelli E., Burki C., Schönlau F.. Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomic subjects. Mol Vis 2008; 14: 1288-1292, 2008.

 

Dr. Stefan Siebrecht, Pycnogenol für Augengesundheit, Vitalstoffe 3, 28-32, 2014

 

Frank Schönlau, P. Rohdewald – Pycnogenol (OPC) for diabetic retinopathy. A review. Int Ophtalomol 24: 161-171, 2001

 

Wissenschaftlicher Bericht über die Effektivität und Toleranz von OPC bei der Behandlung diabetischer Retinopathie auf der Basis eines klinischen Vergleichstests, Leydhecker, H. C. W, Universitäts-Augenklinik, Wurzburg

Hemorrhoids

Effect of OPCs - Hemorrhoids

 

Contrary to the common opinion of many people, hemorrhoids are basically important for the optimal function of the rectum and its closing function. Only in a morbid enlarged condition or when they sag lower, then hemorrhoids make themselves felt with respective symptoms.

 

Hemorrhoids become noticeable through:

 

·        Itching

·        Anal bleedings

·        Anal wetness

·        Stool smear

 

Since this is a disease which is linked closely to a weak tissue and blood vessel problems of these arteriovenous vessel cushions, it can be prevented by using OPCs. A progression of the suffering from hemorrhoids can be stopped and ideally the regeneration of the tissue can be achieved.

 

OPCs help with hemorrhoids:

 

·        stabilize the collagenous fiber in the tissue

·        seal the vessels of the hemorrhoids and repair them.

·        accelerate  wound healing

·        let inflammations of hemorrhoids subside quicker.

·        neutralize free radicals that take part in the suffering from hemorrhoids.

 

Especially the effect of OPCs on the repair of the collagenous components in the tissue are interesting when it comes to the suffering from hemorrhoids. It can possibly lead to problems with hemorrhoids, when the tissue loses elasticity and stability.

OPCs prevent a weakness of the collagenous structure in the body tissue and are able to repair already existing tissue weaknesses.

 

In order to prevent suffering from hemorrhoids you can take 1 - 2 mg OPCs / kg bodyweight a day. If possible, you should take them in-between meals on an empty stomach, so that the body can absorb the most of the OPCs.

 

If hemorrhoids are already present in a form like they are described above, you can take a higher dose of 5 mg OPCs / kg bodyweight. If you, however, have bleedings in this area or massive pain, you should first contact your doctor.

 

 

Sources:

Y.J. Kim / H. J. Park / S.H. Yoon / M. J. Kim / K.H. Leem / J.H. Chung / H.K. Kim: Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4. in: World J. Gastroenterol. 11(30) (2005), 4674-4678

 

Chronic administration of dietary grape seed extract increases colonic expression of gut tight junction protein occludin and reduces fecal calprotectin: a secondary analysis of healthy Wistar Furth rats; By Goodrich, Katheryn M.; Fundaro, Gabrielle; Griffin, Laura E.; Grant, Ar'Quette; Hulver, Matthew W.; Ponder, Monica A.; Neilson, Andrew P.

 

https://de.m.wikipedia.org/wiki/Hämorrhoiden

G. Pühse, F. Raulf: Das Hämorrhoidalleiden. In: Urologe A. Band 46, Nummer 3, März 2007, S. W303–W314, ISSN 0340-2592. doi:10.1007/s00120-006-1281-6. PMID 17294153. (Review).

 

Inflammation and Nutrition, Anon. Medical Nutrition, 42-5 (1989)

 

Plant extract with a proanthocyanadins content as therapeutic agent having radical scavenging effect and use thereof, United States Patent Nr. 4.698.360 (1987)

 

Dr. Walter Brohmüller Scholte, Gabriele Simon & Helmut Achterath. „OPC das Super-Antioxidans.“ iBook 2015

 

Stabilisation du collagene par des oligomeres procyanidoliques; Acta Therapeutica 7:101-5 (1981).

House Dust

Effect of OPCs - House Dust

 

House dust is known to be allergenic and results in a lot of respective allergic symptoms in many people. The house dust allergy is mainly triggered by the mites that are inside of the house dust. Their feces, eggs and body parts can lead to allergic reactions. But also pollen and other allergens are part of the house dust and can lead to health issues, like allergic induced lung and skin diseases for sensitive people.

 

With the help of OPCs you can reduce the reactions of house dust and fight off symptoms successfully. Of course the reduction of house dust should be the first measure. By taking OPCs, you can relieve the symptoms and stabilize the immune system within a short amount of time:

 

OPCs reduce reactions to house dust:

 

OPCs minimize inflammatory mediators like histamine.

OPCs can be successfully used for asthmatic afflictions.

OPCs stabilize the immune system also when it comes to house dust allergies.

OPCs are the strongest antioxidant and eliminate free radicals.

OPCs reduce allergic reactions that are triggered by house dust.

 

Ideally, you prevent house dust allergies in time by taking 1 mg OPCs per kg bodyweight every day and by also adding 80mg of vitamin C a day.

 

If you already have allergic reactions you can increase the dose from 1 mg OPCs a day to 5 mg OPCs a day in order to ease the symptoms and to stabilize the immune system.

 

Sources:

 

Shear stress and aortic histamine synthesis; De- Forrest, Jack M. und Hollis, Theodore M, Amer. J. Physiol. 234(6) H701-5 (1978)

 

Khanna S, et al. Dermal wound healing properties of redox-active grape seed proantho- cyanidins. Free Radic Biol Med 2002; 33(8): 1089–96

 

Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR. Pycnogenol in the Management of Asthma. J Med Food. 2001;4(4):201- 209

 

Inflammation and Nutrition, Anon. Medical Nutrition (Medizinische Ernährung), 42-5 (Herbst 1989)

 

Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 2004;41(8):825-832.

Skin

Effect of OPCs - Skin

The skin profits to a special degree from the features of the OPCs. The extracts, that have been obtained from French grape seeds and pine bark, have the highest OPC (oligomer proanthocyanidin) amount and are perfect for treating the skin from the inside as well as the outside. Due to their structure, the OPCs are able to repair collagenous tissue better than any other nutrient. Thereby certain building blocks of the OPCs are being deposited in the fragments of the skin collagen, which can be compared to a ladder where one broken spoke is being replaced by a new stabile one.

 

With this incorporation of OPCs into the collagen the skin tissue is made flexible and elastic again and gets new stability at the same time. The capacity for the incorporation of liquid is being improved and on top of that, the OPCs help the skin to be better supplied with nutrients. At the same time the buildup of "waste products" is being improved and their removal from the cells is made easier.

 

OPCs are also known to be the most effective nutrient for the elimination of free radicals and are therefore used as the most effective antioxidant. Since our skin has to suffer from environmental influences every single day and therefore is in danger to age must quicker, one should take OPCs to fight off and prevent the attacks of free radicals. When taking OPCs you should pay attention to also take vitamin C, since OPCs increase the antioxidant effect of vitamin C 10-fold and vitamin C is also essential for the collagen buildup of the skin.

 

The nutrient synergy complex from OPCs + Vitamin C have the following effects on the skin:

 

Optimal collagen buildup of the skin.

Improves the water content of the skin.

Protects the skin from early aging.

Repels the attacks of free radicals on the skin.

Optimizes the nutrient supply of the skin cells.

Increases and improves the healing of skin damages.

Takes part in smoothing the skin. Wrinkles are being reduced. Age marks disappear.

 

The high effect of OPCs show especially clearly when it comes to the skin. By using OPCs in combination with vitamin C, the skin can look very different in just a short amount of time. A lot of users report very early much fresher and younger skin.

 

The protection and the care of the skin with the help of OPCs can work from the inside and the outside.

 

Special tip for the outer application of OPCs on the skin:

 

1.     Use a compound in capsule form without additives and help substances, which also contains vitamin C in a natural form if possible.

2.     Buy a natural aloe-vera gel and fill 10 ml (only for the skin in the face) up to 20 ml (bigger body parts) into a water glass.

3.     Depending on the amount you now open one or more capsules (it's ideally if you can at least take 50 mg in to 10 ml of gel and put the powder into the glass with the aloe vera. In order to do that, just pull on both ends of one capsule - the customary capsules are two-piece capsules.

4.     Mix the gel with the powder until the powder is fully dissolved and the geld has a slightly brown-reddish color.

5.     Do a compatibility test on the back of your hand in order to make sure that you'll not have an allergic reaction to one or more components of the gels (even though one can assume that an allergic person can fight off existing skin symptoms with this mixture).

6.     Apply the aloe vera mixture in the evening.

 

In the morning you'll be surprised how the skin looks alone on the morning - often even after just applying it once, you can see a clear visible smoothening and skin irritations are gone over night.

 

Repeat this procedure until the desired results are achieved. If you have open wounds spread the gel around the wound - not directly into the skin wound.

 

With the aloe vera gel, the OPCs are transported very deep into the skin layers and the synergetic effects of the OPCs strengthen the skin protection and healing features of the aloe vera gel and the vitamin C. At the same time the formation of collagen is being innervated so much stronger than any other measure could do it.

 

If you now take 1 - 2 mg of OPCs per kg bodyweight as a supplement to your normal nutrition, you treat your skin from the inside and outside - there's nothing more you can do. This form of application of nutrients in order to protect and care for the skin is, in my experience, the most effective one if you disregard a bath in the Dead Sea or rubbing in the mud from the Dead Sea.

 

Sources:

 

Hughes-Formelia B., Wunderlich O., et al., „Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins.“;Skin Pharmacol Physiol. 2007;20(1):43-9. Epub 2006 Oct 11

 

Fulton, J. E., The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing. J Dermatol Surg Oncol. 1990 May, 16 (5) 460 - 7..

Heart Attack

Effect of OPCs - Heart Attack

During a heart attack, the circulation of the heart is so much impaired that a part of the heart (at least for a short amount of time) is cut-off the blood supply and damaged. This can lead to heart failure. The danger of suffering from heart attack increases when the blood vessels are in bad condition and if either arteriosclerosis or similar preconditions exist.

 

In order to prevent heart attack, which still is one of the most common death causes in industrial nations, you don’t do many things.

 

The most important measures in order to prevent heart attack:

 

·        Lots of movement

·        Conscious nutrition

·        Reduction of stress factors

 

If you integrate these aspects into your daily life you already did a lot for the health of your cardio-vascular system.

 

On top of that you can increase these factors by integrating OPCs into your daily nutrient supply. These phyto-nutrients from French pine bark and grape seed extracts are extremely effective in regards to the health of the blood vessels. Since decades, the OPCs are being used to prevent heart attack and also make sense after a heart attack, when it's about the regeneration. In French clinics, OPCs (according to the method of the inventor Prof. Dr. Jacques Masquelier) are approved for treatment, since this natural active agent has outstanding effects on the cardio-vascular system.

 

OPCs for the prevention of heart attack and for aftercare:

 

OPCs help with the healing of arteriosclerosis.

OPCs help to dismantle and prevent edemata in the body.

OPCs improve the circulation and lower the blood viscosity.

OPCs repair damaged tissue with optimal collagen regeneration.

OPCs protect you from free radicals resp. from excessive oxidation processes.

OPCs optimize cholesterol levels.

OPCs help to heal inflammation in the body faster.

 

In order to prevent heart attack, the above mentioned "healthy lifestyle" is the first step. Additionally you can take 1 mg of OPCs / kg bodyweight per day and make a special nutritionally contribution that already establishes a good protection.

For the aftercare, the dose can be increased to 50 mg OPCs / kg bodyweight per day after talking to your doctor.

Due to the fact that OPCs form a nutrient-synergy complex with vitamin C (10-fold increase of the effect of vitamin C!) you should at least take 80mg vitamin C per day. Vitamin C is very important for the collagenous synthesis in the body and the heart profits accordingly from the vitamin C.

 

Sources:

Protective effeet of wine in laboratory animals fed a cholesterol-enriched diet. FayMorgan, A., Brinner, L., Plaa, C.B. und Stone, M.M., Amer. J. Physiol. 189:290 (1957)

 

Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine. 2000;7(5):383-388

 

Cholesterol and foam cell control with OPC: The atherosclerotic antidote. White, David, Internationale Konferenz der OPC-Forschung, Bordeaux, Frankreich (4.-6. Oktober 1990)

 

Eine neue Therapie für Venenkrankheiten, Feine-Haake, G., Zeitschrift für Allgemeinmedizin, 51:7, 839

 

Stabilisation du collagene par des oligomeres procyanidoliques; Acta Therapeutica 7:101-5 (1981).

Cardiovascular System

Effect of OPCs - Cardiovascular System

 With the help of OPCs, the oligomer proanthocyanidins, you have the opportunity to protect your cardiovascular system. Since years already, OPCs are being used as a medication in France when it's about the treatment of cardiovascular diseases.

 

The OPCs are plant substances that were extracted for the first time in the mid of the 20th century the French researcher Prof. Dr. Jacques Masquelier with a unique technique.  Very soon it was obvious that the regular intake of OPCs of people who suffer from cardiovascular problems -  especially problems in the blood vessels - could enormously profit from OPCs and they improved their health very quickly.

 

The effects of OPCs on the cardiovascular system can on the one hand be explained because the OPCs are able to repair attacked collagenous structures and on the other hand protects the body from free radicals. The better the protection of free radicals works, the less attack surface offers the cardiovascular system to possible disease triggers.

 

Effects of OPCs in relation to the cardiovascular system:

 

OPCs protect the cardiovascular system from free radicals.

OPCs repair collagenous structures in the cardiovascular system.

OPCs help free the cardiovascular system from arteriosclerosis.

OPCs reduce the inflammation mediators.

OPCs increase the healing process.

 

If you want to protect your cardiovascular system from diseases, you can take 1 mg of OPCs / kg bodyweight a day. If you already have cardiovascular diseases, you can talk to your doctor and possibly increase the dose of OPCs to 5 mg / kg bodyweight / day.

 

Sources:

 

See heart attack and arteriosclerosis

Coronary Vessels

Effect of OPCs - Coronary Vessels

 

The coronary vessels are the blood vessels which supply the heart with blood or transport it away from it. The coronary vessels are - as the name implies - placed around the heart like a corona. When the coronary vessels are damaged, the heart muscle can maybe not function well anymore and that is when you talk about a coronary heart disease that can lead to a heart attack in the worst case, if an artery of the coronary vessels suffers from an occlusion.

 

Since OPCs are able to overhaul blood vessels again and to work against arteriosclerosis, the usage of these plant substances for the protection of the coronary vessels is very helpful. Since decades, OPCs are being used for diseases of the blood vessels in France with great success. The effect of OPCs has been researched very well and documented by Prof. Dr. Jacques Masquelier.

 

The main effect of OPCs are:

 

·        Eliminating free radicals and their effect as strongest antioxidant.

·        Repairing of dangerous parts in the collagenous tissue.

·        Increases the effect of vitamin C and E 10-fold

 

With these 3 main effects alone, the coronary vessels already profit to a special degree. At a daily amount of only 1 mg OPC / kg bodyweight, you can protect the coronary vessels in a nutritionally way. If you already have coronary heart disease it is possible to increase the dose of OPCs to 5 mg OPCs / kg bodyweight per day, after consulting you doctor.

 

Sources:

Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res. 2002;16 Suppl 1:S1-5.

Petrassi C, Mastromarino A, Spartera C. Pycnogenol in chronic venous insufficiency. Phytomedicine. 2000;7(5):383-388

Protective effeet of wine in laboratory animals fed a cholesterol-enriched diet. FayMorgan, A., Brinner, L., Plaa, C.B. und Stone, M.M., Amer. J. Physiol. 189:290 (1957)

Procyanidins from pine bark: Relationships between structure, composition and antiradical activity, 2007 Food Chemistry; María Jerez, Sonia Touriño, Jorge Sineiro, Josep Lluís Torres, María José Núñez

Eine neue Therapie für Venenkrankheiten, Feine-Haake, G., Zeitschrift für Allgemeinmedizin, 51:7, 839

Arcangeli P. Pycnogenol in chronic venous insufficiency. Fitoterapia. 2000;71(3):236-244

Jerez et al., „A comparison between bark extracts from Pinus pinaster and Pinus radiata: Antioxidant activity and procyanidin composition“; 2005; DOI:10.1016/ j.foodchem.2005.09.064

Cholesterol and foam cell control with OPC: The atherosclerotic antidote White, David, Internationale Konferenz der OPC-Forschung, Bordeaux, Frankreich,1990

Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (pinus maritima) bark, pycnogenol 1999 Free Radical Biology and Medicine, L Packer, G Rimbach, F Virgili

Hayfever

Effect of OPCs - Endocrine System

 

When it comes to the effect of OPCs on the hormonal system, there are many positive experiences, especially about the area of the female hormonal system and particularly the PMS problem. Unfortunately it's not entirely clear how the OPCs directly influence the hormonal system and it is presumed that the positive effects, especially with PMS, are being pushed through the optimization of the immune system. This way, the hormonal system would directly profit from the OPCs.

 

The indirect effect of OPCs on certain body areas is a phenomenon which can be due to the general structural and metabolic effects of OPCs. With the general regenerative effects of OPCs the processes in the body, which are hard to directly respond to, are being put into order again. It's probably similar to the hormonal system and we hope that the links become clearer in scientific studies.

 

In PMS testes, however, with 165 women, who took every day 200mg of OPCs for 4 months from the 14. - 28. day of the respective cycle, 60% showed an improvement after 2 months. After 2 more months it was even 80% that felt a relief of their discomforts thanks to OPCs.

 

If you want to harmonize your hormonal system then we suggest to take 1 mg OPC / kg bodyweight every day. If the hormonal system is already out of balance you can increase the dose to 400 mg OPCs / day. Higher doses do not have a stronger effect.

Endocrine System

Effect of OPCs - Endocrine System

 

When it comes to the effect of OPCs on the hormonal system, there are many positive experiences, especially about the area of the female hormonal system and particularly the PMS problem. Unfortunately it's not entirely clear how the OPCs directly influence the hormonal system and it is presumed that the positive effects, especially with PMS, are being pushed through the optimization of the immune system. This way, the hormonal system would directly profit from the OPCs.

 

The indirect effect of OPCs on certain body areas is a phenomenon which can be due to the general structural and metabolic effects of OPCs. With the general regenerative effects of OPCs the processes in the body, which are hard to directly respond to, are being put into order again. It's probably similar to the hormonal system and we hope that the links become clearer in scientific studies.

 

In PMS testes, however, with 165 women, who took every day 200mg of OPCs for 4 months from the 14. - 28. day of the respective cycle, 60% showed an improvement after 2 months. After 2 more months it was even 80% that felt a relief of their discomforts thanks to OPCs.

 

If you want to harmonize your hormonal system then we suggest to take 1 mg OPC / kg bodyweight every day. If the hormonal system is already out of balance you can increase the dose to 400 mg OPCs / day. Higher doses do not have a stronger effect.

Immune System

Effect of OPCs - Immune System

The immune system has the task to protect the body from harmful influences resp. to eliminate / neutralize  already existing harmful substances or organisms in the body. Thereby the immune system helps itself out with many strategies that serve to stop the increase of harmful organisms and to kill them off. Harmful substances are being neutralized and wicked away. This is the ideal case. Our immune system is extremely burdened and the body's defenses can be affected very much with the free radicals and other environmental influences.

 

With the usage of OPCs, the immune system can be supported to a special degree, since OPCs are able to eliminate free radicals. This way the immune system is being unburdened and the body's defenses increase again. On top of that, the OPCs stabilize cell structures, repair tissue in the body and reduce inflammatory processes, so that the immune system gets enough energy again in order to do the extensive defense work in the body.

 

OPCs help the immune system

 

  • Inflammations subside faster.

  • Tissue damages are being repaired faster.

  • Free radicals are eliminated / neutralized by.

  • The circulation is being improved with the help of.

  • With the OPCs, the cells are being nourished better with nutrients.

  • The removal of harmful substances from the cells is being optimized with OPCs.

 

This is just a fragment of the effects that can be achieved with OPCs in the body and that serve to give more energy to the immune system in order to keep the defense mechanisms in a high standard.

 

By taking 1 mg of OPCs per kg bodyweight a day you play a part in contributing to a good protection of your immune system. If your immune system is already poor you can increase the dose to 5 mg of OPCs / kg bodyweight a day.

 

Sources:

 

Condensed tannins scavenge active oxygen radicals, Uchida, Shinji, Edamastu, Rei, et.al. Med. Sci., Res., 15:831-2 (1980)

 

Dr. Walter Brohmüller Scholte, Gabriele Simon & Helmut Achterath. „OPC das Super-Antioxidans.“

 

Sen CK, et al. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm. Ann N Y Acad Sci 2002; 957: 239–49

 

Simons, Anne. „Das OPC-Arbeitsbuch.“ MayaMedia. iBooks.

 

Jack Masquelier, Bert Schwitters: A Lifetime Devoted to OPC and Pycnogenols. Jack Masquelier’s pioneering and innovative role in the isolation, identification and application of oligomeric proanthocyanidins / OPC. Rom 1997

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